Effect of age on physiologic and mechanically stressed rat alveolar bone: a cytologic and histochemical study.
Effect of age on physiologic and mechanically stressed rat alveolar bone: a cytologic and histochemical study.
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年龄对生理和机械应力大鼠牙槽骨的影响：细胞学和组织化学研究。
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
H. Ozawa
中科院分区：
文献类型：
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作者：
M. Kabasawa;S. Ejiri;K. Hanada;H. Ozawa
年龄对生理和机械应力大鼠牙槽骨的影响进行了评估，特别关注骨形成和吸收的上颌磨牙部分的1，4，9，16，和24个月大的雄性Fischer大鼠。四环素和钙黄绿素标记的未脱钙切片用于观察共聚焦激光扫描显微镜和接触显微放射照相术。在脱钙切片上观察破骨细胞的定位及成骨细胞的形态学变化。通过在上颌第一和第二磨牙之间插入正畸弹性体施加机械应力，持续7天。结果表明，在生理性大鼠牙槽骨的上颌磨牙断面周围，成骨细胞的成骨活性和破骨细胞的骨吸收活性均随年龄增长而下降。然而，机械应力的大鼠牙槽骨的结果显示，没有证据的数量，大小和破骨细胞和成骨细胞的活性之间的年龄的数值差异，这表明，机械应力激发成骨细胞和破骨细胞同样在成年和年轻的大鼠牙槽骨更高的活性。
The effect of age on physiologic and mechanically stressed rat alveolar bone was assessed with special focus on bone formation and resorption in maxillary molar sections of 1-, 4-, 9-, 16-, and 24-month-old male Fischer rats. Tetracycline- and calcein-labeled undecalcified sections were used for observation by confocal laser scanning microscopy and contact microradiography. The localization of osteoclasts and the morphological change of osteoblasts were observed on decalcified sections. Mechanical stress was applied by an orthodontic elastic inserted between the first and second maxillary molars for 7 days. Results showed that bone-formative activity of osteoblasts and bone-resorptive activity of osteoclasts declined with age around the maxillary molar section of physiologic rat alveolar bone. However, results of mechanically stressed rat alveolar bone revealed no evidence of numerical difference in number, size, and activity of osteoclasts and osteoblasts among the ages, suggesting that mechanical stress provokes a higher activity of osteoblasts and osteoclasts similarly in both adult and younger rat alveolar bone.