CANCER RISK AND LIFE EXPECTANCY OF CHILDREN WITH ULCERATIVE COLITIS
CANCER RISK AND LIFE EXPECTANCY OF CHILDREN WITH ULCERATIVE COLITIS
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DOI：
10.1056/nejm197107012850103
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发表时间：
1971-01-01
影响因子：
158.5
通讯作者：
STICKLER, GB
中科院分区：
文献类型：
--
作者：
DEVROEDE, GJ;TAYLOR, WF;STICKLER, GB
对396名患有溃疡性结肠炎的儿童的长期生存进行的精算分析显示，10、20、30和43岁时的生存率分别为78%、58%、39%和27%。死亡率为每十年20%。对于那些有风险的人来说，患癌症的风险也为每十年 20%，但这始于溃疡性结肠炎的前 10 年。患有累及整个结肠的溃疡性结肠炎的患者，与诊断时疾病仅限于直肠的患者相比，死亡率更高，患癌症的风险也更高。其中 40 名接受直肠结肠切除术的患者在术后第一年最初风险较高，但长期生存率明显提高。
An actuarial analysis of the long-term survival of 396 children suffering from ulcerative colitis showed that survival rates were 78, 58, 39 and 27 per cent at 10, 20, 30 and 43 years, respectively. The death rate was 20 per cent per decade. The risk of the development of cancer was also 20 per cent per decade for those at risk, but this began after the first 10 years of ulcerative colitis. Among patients suffering from ulcerative colitis involving the entire colon, the death rate was higher, and the risk of cancer greater than among those who had disease limited to the rectum at the time of diagnosis. For 40 of these patients who underwent proctocolectomy the long-term survival rate apparently was improved after an initially higher risk in the first year after operation.