GLYCOSYLATION OF RECOMBINANT PROTEIN THERAPEUTICS CONTROL AND FUNCTIONAL IMPLICATIONS
GLYCOSYLATION OF RECOMBINANT PROTEIN THERAPEUTICS CONTROL AND FUNCTIONAL IMPLICATIONS
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DOI：
10.1093/glycob/1.2.115
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发表时间：
1991-01-01
期刊：
影响因子：
4.3
通讯作者：
CUMMING D A
中科院分区：
文献类型：
--
作者：
CUMMING D A
用于人类治疗性给药的重组糖蛋白的发现、开发、生产和临床应用一直是并将继续成为科学和医学领域密集的领域。这项工作引起了人们对翻译后修饰的生物学和治疗意义的极大兴趣，特别是其中最复杂和最复杂的蛋白质糖基化。因此，文献中出现了大量的研究，特别是在过去的几年里，极大地扩展了我们对蛋白质糖基化生物学的理解。本综述旨在总结这些研究，说明蛋白质糖基化通过调节众多生物学属性，对于定义重组疗法的实用性至关重要。
The discovery, development, production and clinical application of recombinant glycoproteins for therapeutic administration in humans has been, and continues to be, an area of intensive scientific and medical effort. This effort has engendered considerable interest in the biological and therapeutic implications of post-translational modifications, particularly the most elaborated and sophisticated of these, protein glycosylation. As a result, numerous studies have appeared in the literature, especially within the past few years, which have greatly expanded our understanding of the biology of protein glycosylation. This review seeks to summarize these studies, illustrating that protein glycosylation, by modulating numerous biological attributes, is of central import in defining the utility of recombinant therapeutics.