Restraint stress during late pregnancy in rats elicits early hypermyelination in the offspring.
Restraint stress during late pregnancy in rats elicits early hypermyelination in the offspring.
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大鼠妊娠后期的束缚应激会引起后代早期髓鞘过度增生。
DOI：
10.1007/bf01001781
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发表时间：
1986
影响因子：
3.6
通讯作者：
Gottesfeld,Z
中科院分区：
文献类型：
--
作者：
Wiggins,RC;Gottesfeld,Z
在怀孕的最后6天，雌性大鼠每天接受2小时的约束应激。在出生后的前2周，应激鼠后代的肾上腺重量高于正常水平。14日龄和21日龄脑髓磷脂浓度高于对照组，40日龄与正常水平相近。早期髓鞘增生可能是早期运动发育的部分原因，正如先前在产前应激大鼠中观察到的那样。
Female rats were subjected to a regular, daily schedule of 2 hr of restraint stress during the final 6 days of pregnancy. During the first 2 postnatal weeks, adrenal weights were greater than normal in the offspring of the stressed dams. The concentration of brain myelin was higher than control at 14 and 21 days of age but similar to normal by day 40. Early hypermyelination may be partly responsible for early motor development, as previously observed in prenatally stressed rats.