Prenatal maternal immune disruption and sex-dependent risk for psychoses
Prenatal maternal immune disruption and sex-dependent risk for psychoses
复制标题
DOI：
10.1017/s0033291714000683
复制
发表时间：
2014-11-01
影响因子：
6.9
通讯作者：
Buka, S. L.
中科院分区：
文献类型：
--
作者：
Goldstein, J. M.;Cherkerzian, S.;Buka, S. L.
背景资料。以前的研究表明，怀孕期间母亲免疫活动的异常会改变后代的大脑发育，并与性别依赖性精神分裂症(SCZ)的风险增加有关。采用嵌套病例对照设计，前瞻性收集产前孕妇血清，检测白介素1β、白介素8、白介素6、肿瘤坏死因子α和白介素10，研究这些细胞因子与88例精神病患者和100例健康对照的性别相关性[SCZ=44例；情感性精神病(AP=44例)]，从妊娠队列中跟踪观察40年。分析包括对多次比较进行调整的性别分层非参数检验，以筛选与SCZ风险相关的细胞因子，然后使用广义估计方程(GEE)模型进行异常子组分析。男性SCZ组产前IL-6水平高于男性对照组，而女性SCZ组低于女性对照组。这一结果得到了偏离亚组分析的支持，与对照组相比，高IL-6水平(最高四分位数)的SCZ男性明显更多[奇比(OR)(75)=3.33，95%可信区间(CI)1.13-9.82]，低TNF-α水平的患病率(
Background. Previous studies suggest that abnormalities in maternal immune activity during pregnancy alter the offspring's brain development and are associated with increased risk for schizophrenia (SCZ) dependent on sex.Method. Using a nested case-control design and prospectively collected prenatal maternal sera from which interleukin (IL)-1 beta, IL-8, IL-6, tumor necrosis factor (TNF)-alpha and IL-10 were assayed, we investigated sex-dependent associations between these cytokines and 88 psychotic cases [SCZ=44; affective psychoses (AP)=44] and 100 healthy controls from a pregnancy cohort followed for >40 years. Analyses included sex-stratified non-parametric tests adjusted for multiple comparisons to screen cytokines associated with SCZ risk, followed by deviant subgroup analyses using generalized estimating equation (GEE) models.Results. There were higher prenatal IL-6 levels among male SCZ than male controls, and lower TNF-alpha levels among female SCZ than female controls. The results were supported by deviant subgroup analyses with significantly more SCZ males with high IL-6 levels (>highest quartile) compared with controls [odd ratio (OR)(75)=3.33, 95% confidence interval (CI) 1.13-9.82], and greater prevalence of low TNF-alpha levels (