Influence of marginal and segmental mandibular resection on the survival rate in patients with squamous cell carcinoma of the inferior parts of the oral cavity
Influence of marginal and segmental mandibular resection on the survival rate in patients with squamous cell carcinoma of the inferior parts of the oral cavity
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DOI：
10.1016/j.jcms.2004.05.005
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发表时间：
2004-10-01
影响因子：
3.1
通讯作者：
Hofele, C
中科院分区：
文献类型：
--
作者：
Wolff, D;Hassfeld, S;Hofele, C
目的：这项回顾性研究的目的是调查是否根治性（节段性切除）或保守性（边缘）切除下颌骨影响患者的生存。患者和方法：对136例下颌骨部分切除术治疗下口腔鳞状细胞癌的患者进行了回顾性评价。54例患者行下颌骨边缘切除术，82例患者行下颌骨节段切除术。平均随访期分别为91.1+/-30.1个月和91.5+/-26.2个月。从患者记录中提取数据，并将其转移到数据库中进行统计学评价。结果边缘切除术的平均生存期为63.0 ± 35.3个月，节段切除术的平均生存期为53.1 ± 32.3个月。根据Kaplan-Meier和显著性检验（对数秩检验）分析总生存率，两组之间的生存率无统计学显著差异（p = 0.1119）。两组的复发、第二原发灶、转移和/或术后并发症的数量相似，即未观察到统计学显著差异（ANOVA，事后Scheffe检验）。结论对于有骨切除指征的病例，边缘切除可获得满意的控制，与节段切除一样有效。(C)2004年欧洲颅颌面外科协会。
Aim: The aim of this retrospective study was to investigate whether radical (segmental resection) or conservative (marginal) resection of mandibular bone influenced patients, survival. Patients and methods: A series of 136 patients selected for partial mandibular resection for the treatment of squamous cell carcinomas of the lower oral cavity was evaluated retrospectively. Fifty-four patients underwent marginal and 82 cases segmental resection of the mandible. The mean follow-up periods were 91.1+/-30.1 months and 91.5+/-26.2 months, respectively. Data was extracted from the patient records and transferred into a database for statistical evaluation. Results Mean survival was 63.0+/-35.3 months for marginal and 53.1+/-32.3 months for segmental resection. The overall survival rate was analysed according to Kaplan-Meier and the test of significance (Log Rank) which yielded no statistically significant difference in the survival rate between both groups (p = 0.1119). Numbers of recurrences, second primaries, metastases and/or postoperative complications were similar in both groups, i.e. no statistically significant differences were observed (ANOVA, Post-hoc Scheffe test). Conclusion In cases with an indication for bone resection, marginal resection may achieve satisfactory control and is as effective as segmental resection. (C) 2004 European Association for Cranio-Maxillofacial Surgery.