Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation
Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation
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DOI：
10.1073/pnas.93.21.11780
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发表时间：
1996-10-15
影响因子：
11.1
通讯作者：
Freeman, GJ
中科院分区：
文献类型：
--
作者：
Hall, KT;Boumsell, L;Freeman, GJ
在这里，我们描述了人类白细胞激活抗原CD100的分子特征，并将其确定为我们所知的免疫系统中的第一个信号素。信号素最近被描述为神经化学反应物，在神经系统发育过程中指导先锋神经元。在这项研究中，我们证明了CD100在体外诱导B细胞聚集并提高其活性。我们发现CD100通过增强B细胞的聚集和存活以及下调CD23的表达来改变CD40-CD40L B细胞信号转导。因此，这些结果表明，以CD100为代表的信号素在免疫系统中也发挥着功能作用。
Herein we describe the molecular characterization of the human leukocyte activation antigen CD100 and identify it as the first semaphorin, to our knowledge, in the immune system. Semaphorins have recently been described as neuronal chemorepellants that direct pioneering neurons during nervous system development. In this study we demonstrate that CD100 induces B cells to aggregate and improves their viability in vitro. We show that CD100 modifies CD40-CD40L B-cell signaling by augmenting B-cell aggregation and survival and down-regulating CD23 expression. Thus, these results suggest that semaphorins as exemplified by CD100 also play a functional role in the immune system.