The relation of body mass index, cardiorespiratory fitness, and all-cause mortality in women
The relation of body mass index, cardiorespiratory fitness, and all-cause mortality in women
复制标题
女性体重指数、心肺功能与全因死亡率的关系
DOI：
10.1038/oby.2002.58
复制
发表时间：
2002-06-01
期刊：
影响因子：
--
通讯作者：
Blair, SN
中科院分区：
文献类型：
--
作者：
Farrell, SW;Braun, L;Blair, SN
目的：为了研究体重指数（BMI），心肺功能（CRF），和所有原因的死亡率women.Research方法和程序：一个队列的妇女（42.9 +/- 10.4岁）的关系进行了评估CRF，身高和体重。参与者被分为三个BMI类别（正常，超重和肥胖）和三个CRF类别（低，中，高）。校正年龄、吸烟和基线健康状况后，确定各组全因死亡的相对危险度（RR）。进行进一步的多变量分析以检查每个预测因子的贡献（例如，年龄、BMI、CRF、吸烟状况和基线健康状况）对全因死亡率的影响，同时控制所有其他预测因子。与正常体重（RR = 1.0）相比，超重（RR = 0.92）和肥胖（RR = 1.58）未显著增加全因死亡风险。与低CRF（RR = 1.0）相比，中（IRR = 0.48）和高（RR = 0.57）CRF与较低的死亡风险显著相关（p = 0.002）。在多变量分析中，中度（RR = 0.49）和高度（RR = 0.57）CRF与相对于低CRF的死亡率降低密切相关（p = 0.003）。与正常体重（RR = 1.0）相比，超重（RR = 0.84）和肥胖（RR = 1.21）与全因死亡率无显著相关性。BMI作为女性全因死亡风险的预测因子，可能会产生误导，除非CRF也被考虑在内。
Objective: To examine the relation of body mass index (BMI), cardiorespiratory fitness (CRF), and all-cause mortality in women.Research Methods and Procedures: A cohort of women (42.9 +/- 10.4 years) was assessed for CRF, height, and weight. Participants were divided into three BMI categories (normal, overweight, and obese) and three CRF categories (low, moderate, and high). After adjustment for age, smoking, and baseline health status, the relative risk (RR) of all-cause mortality was determined for each group. Further multivariate analyses were performed to examine the contribution of each predictor (e.g., age, BMI, CRF, smoking status, and baseline health status) on all-cause mortality while controlling for all other predictors.Results: During follow-up (113,145 woman-years), 195 deaths from all causes occurred. Compared with normal weight (RR = 1.0), overweight (RR = 0.92) and obesity (RR = 1.58) did not significantly increase all-cause mortality risk. Compared with low CRF (RR = 1.0), moderate (IRR = 0.48) and high (RR = 0.57) CRF were associated significantly with lower mortality risk (p = 0.002). In multivariate analyses, moderate (RR = 0.49) and high (RR = 0.57) CRF were strongly associated with decreased mortality relative to low CRF (p = 0.003). Compared with normal weight (RR = 1.0), overweight (RR = 0.84) and obesity (RR = 1.21) were not significantly associated with all-cause mortality.Discussion: Low CRF in women was an important predictor of all-cause mortality. BMI, as a predictor of all-cause mortality risk in women, may be misleading unless CRF is also considered.