DAYTIME HYPERTENSION IN OBSTRUCTIVE SLEEP-APNEA - PREVALENCE AND CONTRIBUTING RISK-FACTORS
DAYTIME HYPERTENSION IN OBSTRUCTIVE SLEEP-APNEA - PREVALENCE AND CONTRIBUTING RISK-FACTORS
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DOI：
10.1378/chest.99.4.861
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发表时间：
1991-04-01
期刊：
影响因子：
9.6
通讯作者：
LEVINSON, PD
中科院分区：
文献类型：
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作者：
MILLMAN, RP;REDLINE, S;LEVINSON, PD
我们研究了阻塞性睡眠呼吸暂停（OSA）患者的现代样本中白天高血压的患病率，并评估了导致这种疾病高血压发展的相对危险因素。在206名男性和女性OSA患者中，有92名（45%）存在白天高血压。逐步Logistic回归分析显示，只有年龄和体重指数（BMI）是高血压的预测因素。然后将152名OSA男性患者的子样本与从地理和种族相似的一般人群中确定的904名男性进行比较。当控制年龄和BMI时，两组中高血压的患病率相同，除了年龄在25至44岁的明显肥胖（BMI > 31 kg/m2）的人群。在该组中，47%的OSA患者患有高血压，而对照组的高血压患者仅为26%（p < 0.05）。我们的数据表明，高血压的患病率在OSA主要与年龄和过度肥胖，在这些患者中看到。在患有OSA的病态肥胖年轻患者中，与OSA直接相关的因素也可能导致高血压的发展。随着年龄的增长，其他竞争风险可能会掩盖任何独立的影响，OSA可能发挥。
We examined the prevalence of daytime hypertension in a modern sample of patients with obstructive sleep apnea (OSA) and assessed the relative risk factors contributing to the development of hypertension in this disorder. Daytime hypertension was present in 92 (45 percent) of 206 male and female patients with OSA. Stepwise logistic regression revealed that only age and body mass index (BMI) were predictors of hypertension in this population. A subsample of 152 male patients with OSA was then compared to 904 men identified from a geographically and ethnically similar general population. When one controlled for age and BMI, the prevalence of hypertension in the two groups was the same except for those aged 25 to 44 years who were markedly obese (BMI > 31 kg/m2). In this group, 47 percent of the patients with OSA were hypertensive vs 26 percent of control subjects (p < 0.05). Our data suggest that the high prevalence of hypertension in OSA is primarily related to age and the excess obesity seen in these patients. In morbidly obese young patients with OSA, factors directly related to OSA may also be contributing to the development of hypertension. With increasing age, other competitive risks may obscure any independent effect that OSA may exert.