ORIGIN OF HUMAN TRIPLOIDS
ORIGIN OF HUMAN TRIPLOIDS
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DOI：
10.1111/j.1469-1809.1978.tb00930.x
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发表时间：
1978-01-01
影响因子：
1.9
通讯作者：
MANUEL, B
中科院分区：
文献类型：
--
作者：
JACOBS, PA;ANGELL, RR;MANUEL, B
通过对26例三倍体胎儿的自然流产调查，确定了其中21例单倍体补体的来源，并通过胎儿和双亲异形的研究确定了其中21例。其中17例为父本来源，3例为母本来源，1例亲本来源不明。最大似然法的最优拟合度为：66.4%的三倍体是分散分裂的结果，23.6%是由雄性第一次减数分裂失败形成的二倍体精子与单倍体卵子受精的结果，10%是由母体第一次减数分裂失败形成的二倍体卵子的结果。回顾了该技术固有的可能误差来源，并将结果与以前发表的数据进行了比较。
A series of 26 triploid fetuses was ascertained in a survey of spontaneous abortuses and the origin of the additional haploid complement determined in 21 of them by the study of fetal and parental heteromorphisms. In 17 the additional haploid set was paternal in origin, in 3 it was maternal in origin and in 1 the parental origin could not be determined. The best fit for the data using a maximum-likelihood method was that 66.4% of the triploids were the result of dispermy, 23.6% the result of fertilization of a haploid ovum by a diploid sperm formed by failure of the 1st meiotic division in the male and 10% the result of a diploid egg formed by failure of the 1st maternal meiotic division. The possible sources of error inherent in the technique are reviewed and the results compared with previously published data.