Lucidity in dementia: A perspective from the NIA
Lucidity in dementia: A perspective from the NIA
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DOI：
10.1016/j.jalz.2019.06.3915
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发表时间：
2019-08-01
影响因子：
14
通讯作者：
McLinden, Kristina A.
中科院分区：
文献类型：
--
作者：
Eldadah, Basil A.;Fazio, Elena M.;McLinden, Kristina A.
在这一期的阿尔茨海默氏症和痴呆症中，Mashour等人提出了一个有趣的假设，即晚期痴呆症的某些表现是可逆的，尽管是短暂的。他们的论文称这种现象为自相矛盾的清醒，是在国家老龄化研究所主办的2018年研讨会之后发表的，该研讨会评估了痴呆症清醒的知识状况，并确定了进一步研究的成熟领域。此后，国家老龄化研究所发布了两份资助机会公告（RFA-AG-20-016和RFA-AG-20-017），以建立这样一个研究计划的基石。进行此类研究的潜在挑战与打开我们对痴呆症理解的新窗口的潜在机会相匹配。这项研究的初步发现可能最终导致研究发现认知下降的新机制，为痴呆症患者确定潜在的预防或治疗方法，为护理人员提供更有效的策略，甚至可能扩大我们对人格和意识本质的理解。爱思唯尔公司出版代表老年痴呆症协会
In this issue of Alzheimer's & Dementia, Mashour et al. propose the intriguing hypothesis that some manifestations of late-stage dementia are reversible, albeit transiently. Calling this phenomenon paradoxical lucidity, their paper follows a 2018 workshop sponsored by the National Institute on Aging that assessed the state of knowledge on lucidity in dementia and identified areas ripe for further study. The National Institute on Aging has since released two funding opportunity announcements (RFA-AG-20-016 and RFA-AG-20-017) to establish the building blocks of such a research program. The potential challenges of conducting such studies are matched by the potential opportunities to open a novel window onto our understanding of dementia. Initial findings from this research may eventually lead to studies that uncover novel mechanisms underlying cognitive decline, identify potential preventive or therapeutic approaches for individuals with dementia, offer more effective strategies for caregivers, and perhaps even expand our understanding of the nature of personhood and consciousness. Published by Elsevier Inc. on behalf of the Alzheimer's Association.