Early patterns of verbal memory impairment in children treated for medulloblastoma
Early patterns of verbal memory impairment in children treated for medulloblastoma
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DOI：
10.1037/0894-4105.20.1.105
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发表时间：
2006-01-01
期刊：
影响因子：
2.4
通讯作者：
Mulhern, RK
中科院分区：
文献类型：
--
作者：
Nagel, BJ;Delis, DC;Mulhern, RK
接受髓母细胞瘤治疗的儿童除了白质和海马神经病理学之外还表现出多种认知缺陷。这项研究对 40 名接受髓母细胞瘤治疗的儿童进行了比较，并与 40 名人口统计学匹配的对照组进行了加州语言学习测试儿童版本（D. C. Delis、J. H. Kramer、E. Kaplan 和 B. A. Ober，1994 年）。结果显示，与对照组相比，患者组的单词回忆指数表现明显较差，此外，识别记忆也较轻微但仍显着较差。这些发现表明，接受髓母细胞瘤治疗的儿童表现出混合型记忆障碍，包括检索和识别缺陷。讨论了这些发现对于了解儿科髓母细胞瘤人群中的神经行为后遗症以及设计用于这些儿童的教育和治疗策略的意义。
Children treated for medulloblastoma demonstrate a variety of cognitive deficits in addition to white matter and hippocampal neuropathology. This study examined 40 children treated for medulloblastoma as compared with 40 demographically matched controls on the California Verbal Learning Test-Children's Version (D. C. Delis, J. H. Kramer, E. Kaplan, & B. A. Ober, 1994). Results revealed significantly poorer performance on indices of word recall in the patient group as compared with the controls in addition to milder but still significantly poorer recognition memory. These findings suggest that children treated for medulloblastoma demonstrate a mixed profile of memory impairment consisting of both retrieval and recognition deficits. Implications of these findings for understanding neurobehavioral sequelae within pediatric medulloblastoma populations and for designing educational and remediation strategies to be used with these children are discussed.