Hyperprolactinemia does not promote testicular recrudescence in photoregressed Siberian hamsters.
Hyperprolactinemia does not promote testicular recrudescence in photoregressed Siberian hamsters.
复制标题
高催乳素血症不会促进光退行西伯利亚仓鼠的睾丸复发。
DOI：
10.1016/0031-9384(93)90062-k
复制
发表时间：
1993
影响因子：
2.9
通讯作者：
Bartness,TJ
中科院分区：
文献类型：
--
作者：
Whitten,RD;Youngstrom,TG;Bartness,TJ
血清催乳素（PRL）的浓度，以及身体，附睾白色脂肪组织（EWAT），睾丸重量，减少在西伯利亚仓鼠（Photopus sungorus sungorus）短光周期曝光。以前，我们已经表明，病变的视交叉上核的下丘脑（SCNx）块睾丸的回归和减少体重和EWAT引起的短日，定时每天皮下注射褪黑激素在松果体切除的西伯利亚仓鼠和显着提高血清PRL浓度。我们还表明，SCNx，以及下丘脑室旁核（PVNx）和PVN腹侧区（subPVN）的病变，促进睾丸复发加速，EWAT和体重增加，血清PRL浓度增加，在短日（SD）圈养，光退化的西伯利亚仓鼠。在这些先前的研究中观察到的睾丸刺激可能是由于损伤诱导的血清PRL浓度增加。因此，本实验的目的是测试实验诱导的高泌乳素血症是否会刺激睾丸复发。这是通过给予光退化，SD圈养的西伯利亚仓鼠绵羊PRL（oPRL）的慢性皮下输注来模拟长日照或病变诱导的仓鼠催乳素（hPRL）血清浓度来实现的。与输注溶剂的对照组相比，在两组中输注oPRL 5周后均未观察到睾丸、体重或EWAT重量增加。这些数据表明，高催乳素血症不是唯一负责刺激睾丸复发的SCNx或PVNx光退化，或SCNx松果体切除仓鼠接受定时褪黑激素输注之前看到的。
Serum prolactin (PRL) concentrations, as well as body, epididymal white adipose tissue (EWAT), and testes weights, decrease in Siberian hamsters (Phodopus sungorus sungorus) following short-photoperiod exposure. Previously, we have shown that lesions of the suprachiasmatic nucleus of the hypothalamus (SCNx) block regression of the testes and decreases in body weight and EWAT caused by short day-like, timed daily subcutaneous melatonin infusions in pinealectomized Siberian hamsters and elevate dramatically serum PRL concentrations. We also have shown that SCNx, as well as lesions of the paraventricular nucleus of the hypothalamus (PVNx) and an area immediately ventral to the PVN (subPVN), promote accelerated testicular recrudescence, increases in EWAT and body weights, and increases in serum PRL concentrations, in short-day (SD)-housed, photoregressed Siberian hamsters. The stimulation of the testes seen in these previous studies could have been due to the lesion-induced increases in serum PRL concentrations. Therefore, the purpose of the present experiment was to test whether experimentally induced hyperprolactinemia could stimulate testicular recrudescence. This was accomplished by giving photoregressed, SD-housed Siberian hamsters chronic subcutaneous infusions of ovine PRL (oPRL) to mimic either long-day- or lesion-induced serum concentrations of hamster prolactin (hPRL). No increase in testes, body, or EWAT weights were observed following 5 weeks of oPRL infusions in either group compared with their vehicle-infused counterparts. These data suggest that hyperprolactinemia was not solely responsible for the stimulation of testicular recrudescence in SCNx or PVNx photoregressed, or SCNx pinealectomized hamsters receiving timed melatonin infusions seen previously.