Biodurability of Single-Walled Carbon Nanotubes Depends on Surface Functionalization.
Biodurability of Single-Walled Carbon Nanotubes Depends on Surface Functionalization.
复制标题
DOI：
10.1016/j.carbon.2010.02.002
复制
发表时间：
2010-06-01
期刊：
影响因子：
10.9
通讯作者：
Kane, Agnes B.
中科院分区：
文献类型：
--
作者：
Liu, Xinyuan;Hurt, Robert H.;Kane, Agnes B.
最近的研究使人们更加关注碳纳米管对人类健康的潜在不利影响，需要进一步开展工作，以更好地描述这些风险并制定风险管理战略。可呼吸纤维的慢性致病潜力的最重要决定因素之一是其生物耐久性，它影响在肺中保留的长期剂量，或生物持久性。本文利用模拟吞噬酶体的体外实验表征了单壁碳纳米管的生物耐久性。生物耐久性取决于纳米管表面功能化的化学性质。具有羧化表面的单壁纳米管具有独特的能力，可以在吞噬溶酶体模拟物中进行90天的降解，从而导致长度减少和超细固体碳质碎片的积累。未改性的、臭氧处理的和芳基磺化的管子在这些条件下不会降解。我们将这种差异归因于酸羧基化的独特化学性质，这不仅会引入COOH表面基团，还会以邻近活性位点的形式对管状石墨骨架造成附带损伤，从而为进一步的氧化降解提供攻击点。这些结果表明，在纳米管的生物降解应用中，表面羧化可以提高安全性或增加功能。
Recent research has led to increased concern about the potential adverse human health impacts of carbon nanotubes, and further work is needed to better characterize those risks and develop risk management strategies. One of the most important determinants of the chronic pathogenic potential of a respirable fiber is its biological durability, which affects the long-term dose retained in the lungs, or biopersistence. The present article characterizes the biodurability of single-walled carbon nanotubes using an in vitro assay simulating the phagolysosome. Biodurability is observed to depend on the chemistry of nanotube surface functionalization. Single-walled nanotubes with carboxylated surfaces are unique in their ability to undergo 90-day degradation in a phagolysosomal simulant leading to length reduction and accumulation of ultrafine solid carbonaceous debris. Unmodified, ozone-treated, and aryl-sulfonated tubes do not degrade under these conditions. We attribute the difference to the unique chemistry of acid carboxylation, which not only introduces COOH surface groups, but also causes collateral damage to the tubular graphenic backbone in the form of neighboring active sites that provide points of attack for further oxidative degradation. These results suggest the strategic use of surface carboxylation in nanotube applications where biodegradation may improve safety or add function.
登录
查看更多内容
影响因子：
10.4
作者：
Fubini, B
通讯作者：
Fubini, B
DOI：
10.1002/anie.197507451
发表时间：
1975-01-01
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH
影响因子：
--
作者：
CRIEGEE, R
通讯作者：
CRIEGEE, R
影响因子：
--
作者：
Hu, Sheng-Liang;Niu, Kai-Yang;Du, Xi-Wen
通讯作者：
Du, Xi-Wen
影响因子：
10.4
作者：
DEMERINGO, A;MORSCHEIDT, C;TIESLER, H
通讯作者：
TIESLER, H
影响因子：
3.3
作者：
Bottini, M;Balasubramanian, C;Mustelin, T
通讯作者：
Mustelin, T