Intermittent Theta-Burst Stimulation for Memory Modulation in a Patient With Mild Cognitive Impairment and Trigeminal Neuralgia.
Intermittent Theta-Burst Stimulation for Memory Modulation in a Patient With Mild Cognitive Impairment and Trigeminal Neuralgia.
复制标题
间歇性 Theta 突发刺激对轻度认知障碍和三叉神经痛患者的记忆调节。
DOI：
10.1097/yct.0000000000000946
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Davis,SimonW
中科院分区：
文献类型：
--
作者：
McAllister,MargaretL;Slayton,MatthewA;Bukhari-Parlakturk,Noreen;Liu,AndyJ;Peterchev,AngelV;Davis,SimonW
Theta脉冲串经颅磁刺激（TBS）是一种非侵入性的调节大脑活动的方法。越来越多的研究集中在TBS是否可以用于改善健康老年人和早期阿尔茨海默病（AD）患者的记忆力，使用间歇性TBS（iTBS）和连续TBS。1然而，AD中神经调节的一些重要因素是潜在共病条件的范围和基于先前存在的神经和精神疾病的纳入或排除标准的景观，这仍在建立中。在这里，我们报告了iTBS后同侧三叉神经痛（TN）发作。参与者是一名74岁的女性，因轻度认知障碍而被招募入本研究;根据脑脊液生物标志物以及TN和偏头痛病史，她患有AD。除了轻度海马和侧顶叶萎缩以及与衰老和AD神经病理学变化相关的轻度至中度脑室周围白质疏松症外，她没有任何脑部异常。使用自我报告问卷对她进行了经颅磁刺激（TMS）禁忌症的筛查，结果显示没有心脏或精神疾病、癫痫家族史、睡眠剥夺或药物滥用。通过在事件发生当天进行尿液药物检测，排除了未公开的物质使用。
Dear Sir, Theta-burst transcranial magnetic stimu-lation (TBS) is a noninvasive approach in modulating brain activity. A growing number of studies have focused on whether TBS can be used to improve memory in healthy older adults and those with incipient Alzheimer disease (AD) using both intermittent TBS (iTBS) and continuous TBS. 1 However, some important factors for neuromodulation in AD are the range of potential comorbid conditions and the landscape of inclusion or exclusion criteria based on preexisting neurological and psychiatric conditions, which are still being established.Here we report an ipsilateral trigeminal neuralgia (TN) attack after iTBS. The participant was a 74-year-old woman recruited into this study because of mild cognitive impairment; she had AD on the basis of cerebrospinal fluid biomarkers and history of TN and migraines. She had no brain abnormalities beyond mild hippocampal and lateral parietal lobe atrophy and mild to moderate periventricular leukoaraiosis associated with aging and AD neuropathological changes. She was screened using a self-report questionnaire for contraindications to transcranial magnetic stimulation (TMS), which revealed no cardiac or psychiatric conditions, family history of epilepsy, sleep deprivation, or drug abuse. Undisclosed substance use was ruled out by using a urine drug test on the day of the event.