SEPTO-HIPPOCAMPAL CONNECTIONS AND THE HIPPOCAMPAL THETA-RHYTHM
SEPTO-HIPPOCAMPAL CONNECTIONS AND THE HIPPOCAMPAL THETA-RHYTHM
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DOI：
10.1007/bf01474253
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发表时间：
1979-01-01
影响因子：
2
通讯作者：
GRAY, JA
中科院分区：
文献类型：
--
作者：
RAWLINS, JNP;FELDON, J;GRAY, JA
记录自发海马theta活动在自由活动的大鼠，之前和之后的各种病变。记录部位[3]用于监测背侧海马、腹侧海马或靠近海马曲部位的活动。在内侧隔区或背外侧隔区进行电解损伤;在穹窿伞或背内侧区进行手术横断。以下病变仅限于内侧隔区，θ被取消整个海马;病变后，仅限于背外侧隔区θ被保留。海马伞病变废除θ在腹侧，但不是背侧海马;背内侧穹窿病变废除它在背侧，但不是腹侧，海马。在一些受试者的海马结构随后染色胆碱酯酶：胆碱酯酶染色损失通常与θ损失，但这是不清楚的弯曲记录网站。Theta取决于内侧隔区的完整性。损伤隔区的海马传入神经会使θ波消失，而损伤反馈传出神经则不会。
Recordings were made of spontaneous hippocampal theta activity in free-moving rats, before and after a variety of lesions. Recording sites [3] were used to monitor activity in the dorsal hippocampus, the ventral hippocampus, or close to the site of the hippocampal flexure. Electrolytic lesions were made in the medial septal area or the dorso-lateral septal area; surgical transections were made of the fimbria or dorso-medial area of the fornix. Following lesions restricted to the medial septal area, theta was abolished throughout the hippocampus; after lesions restricted to the dorso-lateral septal area theta was retained. Fimbria lesions abolished theta in the ventral, but not the dorsal hippocampus; dorso-medial fornix lesions abolished it in the dorsal, but not the ventral, hippocampus. In some subjects the hippocampal formation was subsequently stained for cholinesterase: cholinesterase staining loss was generally associated with theta loss, but this was not clear at the flexure recording site. Theta is dependent upon the integrity of the medial septal area. Damage to hippocampal afferents from the septum does abolish theta, while damaging the feedback efferents does not.