Anorexia nervosa and body dysmorphic disorder are associated with abnormalities in processing visual information.
Anorexia nervosa and body dysmorphic disorder are associated with abnormalities in processing visual information.
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DOI：
10.1017/s0033291715000045
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发表时间：
2015-07
影响因子：
6.9
通讯作者：
Feusner J
中科院分区：
文献类型：
--
作者：
Li W;Lai TM;Bohon C;Loo SK;McCurdy D;Strober M;Bookheimer S;Feusner J
神经性厌食症（AN）和躯体畸形恐惧症（BDD）是以扭曲的体像为特征的两种疾病，它们之间的关系目前研究较少。虽然有证据表明这两种疾病的视觉和视觉空间处理异常，但没有研究直接比较两者。我们使用了两种互补的方式-事件相关电位（ERP）和功能磁共振成像-来测试与早期视觉信号相关的异常活动。我们分别从三组（体重恢复的AN，BDD和健康对照组）中的15名未服药的个体中获取了fMRI和ERP数据，同时他们观看了不同空间频率的面部和房屋的图像。我们使用联合独立成分分析来比较视觉系统的活动。AN和BDD组表现出类似的活动减退，在早期二级视觉处理区域和背侧视觉流时，观看低空间频率的脸，链接到N170组件，以及在早期二级视觉处理区域时，观看低空间频率的房子，链接到P100组件。此外，BDD组在观看与N170成分相关的高空间频率房屋时，梭状皮质表现出过度活跃。这一部分的活动越大，面孔的吸引力等级就越低。结果提供了初步的证据，类似的异常时空激活AN和BDD的外观和非外观相关的刺激的视觉/整体信息。这表明早期视觉系统功能异常的常见表型，这可能有助于感知失真。
Anorexia nervosa (AN) and body dysmorphic disorder (BDD) are characterized by distorted body image and are frequently comorbid with each other, although their relationship remains little studied. While there is evidence of abnormalities in visual and visuospatial processing in both disorders, no study has directly compared the two. We used two complementary modalities – event-related potentials (ERP) and fMRI – to test for abnormal activity associated with early visual signaling. We acquired fMRI and ERP data in separate sessions from 15 unmedicated individuals in each of three groups (weight-restored AN, BDD, and healthy controls) while they viewed images of faces and houses of different spatial frequencies. We used joint independent component analyses to compare activity in visual systems. AN and BDD groups demonstrated similar hypoactivity in early secondary visual processing regions and the dorsal visual stream when viewing low spatial frequency faces, linked to the N170 component, as well as in early secondary visual processing regions when viewing low spatial frequency houses, linked to the P100 component. Additionally, the BDD group exhibited hyperactivity in fusiform cortex when viewing high spatial frequency houses, linked to the N170 component. Greater activity in this component was associated with lower attractiveness ratings of faces. Results provide preliminary evidence of similar abnormal spatio-temporal activation in AN and BDD for configural/holistic information for appearance- and nonappearance-related stimuli. This suggests a common phenotype of abnormal early visual system functioning, which may contribute to perceptual distortions.