Aptamers as therapeutic and diagnostic reagents: problems and prospects
Aptamers as therapeutic and diagnostic reagents: problems and prospects
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DOI：
10.1016/s1367-5931(97)80102-0
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发表时间：
1997-06-01
影响因子：
7.8
通讯作者：
Ellington, AD
中科院分区：
文献类型：
--
作者：
Osborne, SE;Matsumura, I;Ellington, AD
适配子是结合特定配体的核酸分子。在过去的几年里，适体作为治疗和诊断试剂的应用障碍已经被克服。特别是，结合生物医学相关靶点的适体已被证明在改变细胞代谢方面是有效的。这种适配子可以通过化学修饰来稳定，并有可能在体内使用。研究人员已经开始设计基于适体的诊断分析，可能会与更传统的免疫分析相抗衡。
Aptamers are nucleic acid molecules that bind specific ligands. Barriers to the application of aptamers as therapeutic and diagnostic reagents have been overcome in the past several years. In particular, aptamers that bind biomedically relevant targets have proven to be efficacious at modifying cellular metabolism. Such aptamers can be stabilized by chemical modifications and potentially used in vivo. Researchers have begun to devise aptamer-based diagnostic assays that may rival more conventional immunoassays.