Hyperintensities and fronto-subcortical atrophy on MRI are substrates of mild cognitive deficits after stroke
Hyperintensities and fronto-subcortical atrophy on MRI are substrates of mild cognitive deficits after stroke
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DOI：
10.1159/000070684
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发表时间：
2003-01-01
影响因子：
2.4
通讯作者：
O'Brien, J
中科院分区：
文献类型：
--
作者：
Burton, E;Ballard, C;O'Brien, J
目的：探讨脑卒中后早期神经心理认知功能障碍的MRI相关性。法对50名>75岁的卒中幸存者[38名年龄相关性认知功能下降（AACD）]和15名年龄匹配的对照者进行详细的神经心理学评估（注意力和工作记忆）。使用1.5特斯拉通用电气MRI扫描仪。对白色高信号（WMH）进行标准化视觉评级。使用基于体素的形态测定法评估灰质体积。结果：关联的处理速度和执行功能和WMH的严重程度在关键领域。此外，额皮质下回路萎缩与AACD相关。结论：注意和执行功能障碍是由WMH在额-纹-丘脑-额叶回路的基础。额叶萎缩被认为是脑卒中患者认知功能下降的一种新的基础。版权所有（C）2003 S. Karger AG，巴塞尔。
Aim: The current study determines the MRI correlations of the early neuropsychological post-stroke cognitive deficits. Method. Detailed neuropsychological assessments (attention and working memory) were undertaken in 50 stroke survivors >75 years of age [38 with ageing-associated cognitive decline (AACD)] and 15 age-matched controls. A 1.5-tesla General Electric MRI scanner was used. Standardized visual ratings were undertaken of white matter hyperintensities (WMH). Grey matter volumes were assessed using voxel-based morphometery. Results: Associations were identified between processing speed and executive function and the severity of WMH in key areas. In addition, atrophy in the fronto-subcortical circuits was associated with AACD. Conclusion: Attentional and executive impairments are underpinned by WMH in fronto-striato-thalamo-frontal circuits. Frontal atrophy is identified as a novel substrate of cognitive decline in stroke patients. Copyright (C) 2003 S. Karger AG, Basel.