A limited cerebellar contribution to suprasecond timing across differing task demands.
A limited cerebellar contribution to suprasecond timing across differing task demands.
复制标题
小脑对不同任务需求的超秒计时贡献有限。
DOI：
10.1037/bne0000531
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发表时间：
2022
影响因子：
1.9
通讯作者：
Parker,KrystalL
中科院分区：
文献类型：
--
作者：
Heslin,KelseyA;Purnell,JessicaR;DeCorte,BenjaminJ;Parker,KrystalL
小脑参与超秒间隔计时(即，计时在秒到分钟的范围内)是有争议的。来自人类、非人类灵长类动物和啮齿动物的有限证据表明，小脑外侧核，包括小脑外侧核(LCN)，可能是成功的超秒计时操作所必需的。然而，许多现有的研究都存在陷阱，例如有限的时间结果衡量标准和混乱的任务要求。此外，许多现有的研究依赖于训练有素的受试者。这种方法可能是一个缺点，因为假设小脑进行持续的纠错以限制时间变异性。由于只使用有经验的受试者，过去的计时研究可能错过了小脑参与的一个关键窗口。在这里描述的实验中，我们在三个不同的峰值间隔计时任务中对大鼠LCN进行了药物灭活。我们组织了我们的任务，以解决过去的混乱，收集时间可变性测量，并表征目标持续时间获取期间的表现。在这些不同的任务中，我们没有发现小脑参与超秒间隔计时的强烈支持。我们的发现支持现有的区分小脑是一个亚秒时间间隔的大脑区域的观点。(数据库记录(C)2022 APA，保留所有权利)
The involvement of the cerebellum in suprasecond interval timing (ie, timing in the seconds to minutes range) is controversial. A limited amount of evidence from humans, nonhuman primates, and rodents has shown that the lateral cerebellum, including the lateral cerebellar nucleus (LCN), may be necessary for successful suprasecond timing performance. However, many existing studies have pitfalls, such as limited timing outcome measures and confounded task demands. In addition, many existing studies relied on well-trained subjects. This approach may be a drawback, as the cerebellum is hypothesized to carry out ongoing error correction to limit timing variability. By using only experienced subjects, past timing studies may have missed a critical window of cerebellar involvement. In the experiments described here, we pharmacologically inactivated the rat LCN across three different peak interval timing tasks. We structured our tasks to address past confounds, collect timing variability measures, and characterize performance during target duration acquisition. Across these various tasks, we did not find strong support for cerebellar involvement in suprasecond interval timing. Our findings support the existing distinction of the cerebellum as a subsecond interval timing brain region.(PsycInfo Database Record (c) 2022 APA, all rights reserved)