Theta oscillation during auditory change detection: An MEG study
Theta oscillation during auditory change detection: An MEG study
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DOI：
10.1016/j.biopsycho.2009.01.007
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发表时间：
2009-04-01
影响因子：
2.6
通讯作者：
Lin, Yung-Yang
中科院分区：
文献类型：
--
作者：
Hsiao, Fu-Jung;Wu, Zin-An;Lin, Yung-Yang
为研究听觉异常前注意检测过程中脑电振荡的相位和功率特征，采用Oddball范式记录了10名健康受试者的脑磁图反应。当受试者正在观看无声电影时，标准音调（1000 Hz频率，100 ms持续时间）及其持续时间偏差（50 ms持续时间，概率为15%）被随机双耳传递。除了用等效电流偶极子模型定位磁失配负性（MMMm）对应物外，我们还通过采用基于Morlet小波的分析测量了对标准和偏差刺激的振荡响应的锁相值（PLV）和功率变化。异常发生后150-200 ms达到峰值的MMNm信号位于右侧半球振幅较大的双侧颞区。然后50 ms后，无论是标准或偏差刺激的发病，我们观察到增加PLV和功率的θ和α振荡在双侧颞区。右侧大脑半球θ和α活动的PLV显著大于左侧大脑半球（P < 0.001）。与标准刺激相比，偏差刺激在150-300 ms时诱发右颞区反应的θ PLV更大（P < 0.001），在50-300 ms时诱发右颞区反应的θ功率变化更大（P < 0.05）。在110-250 ms时，右侧额叶出现明显的θ相位锁定（P < 0.01）。我们目前的数据表明，一个明显的相位和功率调制的声音引起的θ振荡可能表征的变化检测处理的颞-额网络所反映的不匹配负性。(C)2009爱思唯尔有限公司版权所有。
To study the phase and power characteristics of brain oscillations during the preattentive detection of auditory deviance, we recorded magnetoencephalographic responses in 10 healthy subjects with an oddball paradigm. As the subject was watching a silent movie, standard tones (1000-Hz frequency, 100-ms duration) and their duration deviants (50-ms duration, probability of 15%) were randomly delivered binaurally. In addition to localizing the magnetic counterpart of mismatch negativity (MMNm) with equivalent current dipole modeling, we also measured the phase-locking value (PLV) and power change of the oscillatory responses to standard and deviant stimuli by employing the Morlet wavelet-based analysis. The MMNm signals peaking at 150-200 ms after the onset of deviant were localized in bilateral temporal regions with larger amplitudes in the right hemisphere. Then 50 ms after the onset of either standard or deviant stimuli, we observed an increase of PLV and power of theta and alpha oscillations in bilateral temporal regions. PLVs of theta and alpha activities to deviant stimuli were significantly larger in the right than left hemisphere (P < 0.001). Compared with standard stimuli, deviants elicited a larger theta PLV (P < 0.001) at 150-300 ms and a larger theta power change (P < 0.05) at 50-300 ms for the responses in the right temporal region. In addition, a prominent theta phase-locking of deviant-elicited responses was found in the right frontal area at 110-250 ms (P < 0.01). Our current data suggest that a pronounced phase and power modulation on sound-elicited theta oscillations might characterize the change detection processing in the temporo-frontal network as reflected by the mismatch negativity. (C) 2009 Elsevier B.V. All rights reserved.