Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation.
Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation.
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Bcl-3：免疫细胞和炎症中的双刃剑
DOI：
10.3389/fimmu.2022.847699
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发表时间：
2022
影响因子：
7.3
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Liu H;Zeng L;Yang Y;Guo C;Wang H
NF - κB转录因子家族控制着许多基因的转录，并调节一系列关键的生物学过程。其活性受IκB蛋白家族调控。Bcl - 3是IκB蛋白家族的一个非典型成员，它调节核因子NF - κB的活性。它可根据所接受的细胞类型和刺激促进或抑制NF - κB靶基因的表达，影响多种细胞功能，如增殖和分化、诱导凋亡以及免疫应答。Bcl - 3也被视为一种环境依赖性细胞反应调节剂，在B细胞发育以及Th细胞的分化、存活和增殖中具有双重作用。此外，它在炎症中也表现出矛盾的作用。目前，除了旨在研究Bcl - 3分子机制的工作外，越来越多的研究聚焦于Bcl - 3在体内对炎症、免疫和恶性肿瘤的影响。在这篇综述中，我们关注Bcl - 3在NF - κB通路调节中的最新进展及其在炎症和免疫细胞中的广泛生理作用，这可能有助于为各种炎症性疾病、免疫缺陷疾病和恶性肿瘤的早期诊断或靶向治疗提供新思路和靶点。
The NF-κB transcription factor family controls the transcription of many genes and regulates a number of pivotal biological processes. Its activity is regulated by the IκB family of proteins. Bcl-3 is an atypical member of the IκB protein family that regulates the activity of nuclear factor NF-κB. It can promote or inhibit the expression of NF-κB target genes according to the received cell type and stimulation, impacting various cell functions, such as proliferation and differentiation, induction of apoptosis and immune response. Bcl-3 is also regarded as an environment-dependent cell response regulator that has dual roles in the development of B cells and the differentiation, survival and proliferation of Th cells. Moreover, it also showed a contradictory role in inflammation. At present, in addition to the work aimed at studying the molecular mechanism of Bcl-3, an increasing number of studies have focused on the effects of Bcl-3 on inflammation, immunity and malignant tumors in vivo. In this review, we focus on the latest progress of Bcl-3 in the regulation of the NF-κB pathway and its extensive physiological role in inflammation and immune cells, which may help to provide new ideas and targets for the early diagnosis or targeted treatment of various inflammatory diseases, immunodeficiency diseases and malignant tumors.
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影响因子：
5.4
作者：
Tassi, Ilaria;Rikhi, Nimisha;Claudio, Estefania;Wang, Hongshan;Tang, Wanhu;Ha, Hye-lin;Saret, Sun;Kaplan, Daniel H.;Siebenlist, Ulrich
通讯作者：
Siebenlist, Ulrich
影响因子：
7.3
作者：
Cheng CS;Feldman KE;Lee J;Verma S;Huang DB;Huynh K;Chang M;Ponomarenko JV;Sun SC;Benedict CA;Ghosh G;Hoffmann A
通讯作者：
Hoffmann A
DOI：
10.1016/j.bbamcr.2014.07.012
发表时间：
2014-11
影响因子：
5.1
作者：
Chang, Tzu-Pei;Vancurova, Ivana
通讯作者：
Vancurova, Ivana
影响因子：
4.8
作者：
Collins, Patricia E.;Kiely, Patrick A.;Carmody, Ruaidhri J.
通讯作者：
Carmody, Ruaidhri J.
影响因子：
11.4
作者：
FRANZOSO, G;BOURS, V;SIEBENLIST, U
通讯作者：
SIEBENLIST, U