QTc interval in a sample of long-term schizophrenia inpatients
QTc interval in a sample of long-term schizophrenia inpatients
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DOI：
10.1016/j.schres.2009.09.041
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发表时间：
2010-01-01
影响因子：
4.5
通讯作者：
de Leon, Jose
中科院分区：
文献类型：
--
作者：
Ramos-Rios, Ramon;Arrojo-Romero, Manuel;de Leon, Jose
这项自然主义研究试图确定相对较多的慢性精神分裂症住院患者中QTc间期延长的患病率，并探索QTc与人口统计学变量、代谢参数和处方治疗的关系。对西班牙一家长期精神病医院的所有住院患者进行横断面调查，以确定QTc间期延长和代谢综合征的患病率。DSM-IV诊断为精神分裂症的样本包括171名白人住院患者，均为西班牙裔。QTc间期延长定义为男性>450 ms，女性>470 ms。使用以QTc为因变量的线性回归模型评估QTc与其他连续变量之间的关系。仅10例患者（6%）出现QTc间期延长; 1例病例可能由低钾血症解释。3例患者（2%）QTc>500 ms。线性回归分析发现，性别、年龄（≥ 50岁）、吸烟、收缩压、HDL胆固醇和心律失常史对QTc间期有显著影响。在控制了显著变量后，平均QTc间期不受抗精神病药物剂量、抗精神病药物治疗类型、长效抗精神病药物的使用或处方的不同抗精神病药物数量的显著影响。我们的研究集中在长期住院的精神分裂症患者中，这些患者经常服用多种抗精神病药物和高剂量抗精神病药物，提示排除低钾血症后QTc间期延长与心律失常史及代谢因素有关，而抗精神病药物或类别的影响不明显。(C)2009 Elsevier B. V.保留所有权利。
This naturalistic study attempted to determine the prevalence of prolonged QTc interval in a relatively large population of inpatients hospitalized with chronic schizophrenia, and to explore QTc relationship with demographic variables, metabolic parameters and prescribed treatments. All inpatients from a Spanish long-term psychiatric hospital were cross-sectionally investigated to determine the prevalence of QTc prolongation and metabolic syndrome. The sample with a DSM-IV diagnosis of schizophrenia included 171 Caucasian inpatients, all of Spanish origin. A prolonged QTc interval was defined as >450 ms in men and >470 ms in women. The relationships between QTc and other continuous variables were assessed using a linear regression model with QTc as the dependent variable. Only 10 patients (6%) had a prolonged QTc interval; one case was possibly explained by hypokalemia. Three patients (2%) had a QTc>500 ms. Gender, old age (>= 50 years old), current smoking, systolic blood pressure, HDL cholesterol and history of arrhythmia were found to have significant effects on QTc interval in a linear regression analysis. After controlling for significant variables, the mean QTc interval was not significantly influenced by antipsychotic dose, type of antipsychotic treatment, the use of depot antipsychotics, or the number of different antipsychotics prescribed, Our study focused on long-term schizophrenia inpatients with frequent antipsychotic polypharmacy and high antipsychotic doses, and suggested that after excluding the case with hypokalemia length of QTc was associated with history of arrhythmias and with metabolic factors, while the effects of antipsychotic compound or class were not so evident. (C) 2009 Elsevier B.V. All rights reserved.