Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer.
Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer.
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脂肪酸氧化和肉碱棕榈酰转移酶 I：癌症的新兴治疗靶点
DOI：
10.1038/cddis.2016.132
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发表时间：
2016-05-19
影响因子：
9
通讯作者：
Deng F
中科院分区：
文献类型：
--
作者：
Qu Q;Zeng F;Liu X;Wang QJ;Deng F
肿瘤细胞表现出独特的代谢适应能力，越来越多地被视为新的和特定的癌症治疗的潜在靶点。在这些靶标中，肉碱棕榈酰转移酶系统负责将长链脂肪酸(FA)从细胞质输送到线粒体进行氧化，其中肉碱棕榈酰转移酶I(CPTI)催化脂肪酸氧化的限速步骤(FAO)。随着人们对脂肪酸氧化在癌症中的关键作用的认识日益加深，CPTI作为癌症代谢机制中的关键介质重新受到关注。CPTI通过三磷酸腺苷和NADPH的产生激活粮农组织并促进癌症生长，构成癌症代谢适应的重要组成部分。此外，CPTI还在功能上与其他关键途径和因子交织在一起，调节肿瘤细胞的基因表达和凋亡。在这里，我们总结了最新的发现，并更新了对FAO和CPTI在癌症中的理解，为该酶作为一种新的潜在分子靶点在癌症治疗干预中的应用提供了理论基础。
Tumor cells exhibit unique metabolic adaptations that are increasingly viewed as potential targets for novel and specific cancer therapies. Among these targets, the carnitine palmitoyltransferase system is responsible for delivering the long-chain fatty acid (FA) from cytoplasm into mitochondria for oxidation, where carnitine palmitoyltransferase I (CPTI) catalyzes the rate-limiting step of fatty acid oxidation (FAO). With increasing understanding of the crucial role had by fatty acid oxidation in cancer, CPTI has received renewed attention as a pivotal mediator in cancer metabolic mechanism. CPTI activates FAO and fuels cancer growth via ATP and NADPH production, constituting an essential part of cancer metabolism adaptation. Moreover, CPTI also functionally intertwines with other key pathways and factors to regulate gene expression and apoptosis of cancer cell. Here, we summarize recent findings and update the current understanding of FAO and CPTI in cancer and provide theoretical basis for this enzyme as an emerging potential molecular target in cancer therapeutic intervention.