Neurochemical studies on imprinting behavior in chick and duckling
Neurochemical studies on imprinting behavior in chick and duckling
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雏鸭印记行为的神经化学研究
DOI：
10.1007/bf00964979
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发表时间：
1985
影响因子：
4.4
通讯作者：
Y. Tsukada
中科院分区：
文献类型：
--
作者：
K. Takamatsu;Y. Tsukada
观察内侧上纹状体腹侧（MHV）和外侧新纹状体（LN）部分损伤对刺激行为的影响。MHV的双侧病变严重损害了雏鸭的印迹行为，但LN的病变并不损害这种行为。另一方面，MHV损伤的鸟类仍具有亮度辨别学习能力，视觉协调能力较好。使用神经传递阻断剂研究了控制MHV中印记行为的神经递质候选物。6-羟基多巴胺（6-OHDA）和氟哌啶醇注入MHV没有特定的影响印迹行为，虽然在MHV中的儿茶酚胺含量明显下降，运动活性强烈抑制。MHV内注射阿托品可引起跟随行为的明显损害，但自发活动不受影响。其他部位注射阿托品无明显效果。α-银环蛇毒素对印迹或运动活性均无影响。MHV内注射海人酸后，MHV区谷氨酸含量下降，24小时达高峰。然而，印迹行为在注射后3小时已经受损，但在24小时已经恢复。谷氨酸注射也有同样的作用。研究了蛋白质合成抑制剂对印迹获得过程的影响。在第一次暴露于印迹刺激后2小时内，将放线菌酮（CHX）注射到MHV中显著损害印迹的获得。当24小时后给予CHX时，印迹行为不受影响。
The effect of lesiens in the parts of medial hyperstriatum ventrale (MHV) or lateral neostriatum (LN) on impriting behavior was examined. Bilateral lesions in MHV severely impaired imprinting behavior in ducklings, but lesions in LN did not impair such behavior. On the other hand, the birds lesioned in MHV still had brightness discriminative learning ability with perfect performance of visuomotor coordination. The neurotransmitter candidates controlling imprinting behavior in MHV were investigated using blockers of neurotransmission. 6-Hydroxydopamine (6-OHDA) and haloperidole injected into MHV did not have specific effect on imprinting behavior although catecholamine contents in MHV was clearly decreased and locomotor activity was strongly suppressed. Atropine injection into MHV caused significant impairment of following behavior, but locomotor activity was not affected. The injection of atropine into other region did not have any effect. α-Bungarotoxin showed no effect on either imprinting or locomotor activity. Kainic acid injection into MHV caused the decrease of glutamate content in the MHV region and it reached maximum at 24 hours after injection. However, imprinting behavior was already impaired at 3 hours after injection, but at 24 hours it had been recovered. A same effect was observed by glutamate injection. The effect of protein synthesis inhibitor on the aquisition process of imprinting was investigated. The aquisition of imprinting was significantly impaired by cycloheximide (CHX) injection into MHV within 2 hours after the first exposure to the imprinting stimulus. When CHX was given 24 hours after, imprinting behavior was not affected.