Genetics of Pheochromocytomas and Paragangliomas An Overview on the Recently Implicated Genes MERTK, MET, Fibroblast Growth Factor Receptor 1, and H3F3A
Genetics of Pheochromocytomas and Paragangliomas An Overview on the Recently Implicated Genes MERTK, MET, Fibroblast Growth Factor Receptor 1, and H3F3A
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DOI：
10.1016/j.ecl.2017.01.009
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发表时间：
2017-06-01
影响因子：
4.5
通讯作者：
Toledo, Rodrigo Almeida
中科院分区：
文献类型：
--
作者：
Toledo, Rodrigo Almeida
Genomic studies conducted by different centers have uncovered various new genes mutated in pheochromocytomas and paragangliomas (PPGLs) at germline, mosaic, and/or somatic levels, greatly expanding our knowledge of the genetic events occurring in these tumors. The current review focuses on very new findings and discusses the previously not recognized role of MERTK, MET, fibroblast growth factor receptor 1, and H3F3A genes in syndromic and nonsyndromic PPGLs. These 4 new genes were selected because although their association with PPGLs is very recent, mounting evidence was generated that rapidly consolidated the prominence of these genes in the molecular pathogenesis of PPGLs.
