ETHANOL-CONSUMPTION AND BLOOD-PRESSURE
ETHANOL-CONSUMPTION AND BLOOD-PRESSURE
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DOI：
10.1016/0024-3205(83)90734-8
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发表时间：
1983-01-01
期刊：
影响因子：
6.1
通讯作者：
SUTTER, MC
中科院分区：
文献类型：
--
作者：
CHAN, TCK;SUTTER, MC
长期乙醇摄入持续导致雄性Wistar大鼠轻度高血压。与对照组相比，乙醇处理的动物24小时尿量减少，钠潴留明显。用指标稀释法估计总血浆体积，在乙醇处理的动物中观察到血浆体积增加了20%。血管平滑肌对去甲肾上腺素的体外反应在两组动物间无明显差异。乙醇处理动物的血压升高可能与钠潴留和血浆容量扩张有关，而可能与血管反应性改变无关。
Chronic ethanol consumption consistently resulted in mild hypertension in male Wistar rats. The ethanol-treated animals also had reduced 24 h urinary output and significant Na retention when compared to controls. Total plasma volume was estimated using indicator dilution, and an increase of 20% was observed in the ethanol-treated animals. Vascular smooth muscle responsiveness to noradrenaline [norepinephrine] in vitro was not different between the 2 groups of animals. The blood pressure elevation in the ethanol-treated animals was probably associated with Na retention and plasma volume expansion, and probably not related to altered vascular responsiveness.