The importance of redox state in liver damage.
The importance of redox state in liver damage.
复制标题
氧化还原状态在肝损伤中的重要性。
DOI：
10.1016/s1665-2681(19)32099-x
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发表时间：
2004
影响因子：
3.8
通讯作者：
["L. Cesaratto
中科院分区：
文献类型：
--
作者：
["L. Cesaratto
氧化应激是发生在从代谢性到增殖性肝脏疾病的多种肝脏疾病中的主要致病事件，并且是肝移植期间由于缺血/再灌注（I/R）引起的肝损伤的主要原因。ROS的主要来源是肝细胞中的线粒体和细胞色素P450酶、枯否细胞和嗜中性粒细胞。细胞具有严格控制细胞内ROS水平和维持氧化剂和抗氧化剂分子之间平衡的有效分子策略。细胞氧化应激条件是由ROS的产生和细胞的抗氧化防御能力之间的不平衡决定的，并且可以影响主要的细胞组分，包括脂质、蛋白质和DNA。蛋白质是细胞氧化还原状态的重要标志，ROS通过调节蛋白质的结构和功能，影响细胞内信号转导途径，从而影响基因表达谱。虽然肝脏中慢性氧化应激的几种酶（如超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶）和非酶（如4-羟基壬烯醛、谷胱甘肽减少、维生素E、维生素C、丙二醛）标志物是众所周知的，但氧化损伤的早期蛋白质靶点还没有很好地确定。这些标志物的鉴定将能够早期发现肝脏疾病，并将允许监测肝损伤的程度，
Oxidative stress is a major pathogenetic event occurring in several liver disorders ranging from metabolic to proliferative ones, and is a major cause of liver damage due to Ischemia/Reperfusion (I/R) during liver transplantation. The main sources of ROS are represented by mitochondria and cytocrome P450 enzymes in the hepatocyte, by Kupffer cells and by neutrophils. Cells are provided with efficient molecular strategies to strictly control the intracellular ROS level and to maintain the balance between oxidant and antioxidant molecules. A cellular oxidative stress condition is determined by an imbalance between the generation of ROS and the antioxidant defense capacity of the cell and can affect major cellular components including lipids, proteins and DNA. Proteins are very important signposts of cellular redox status and through their structure/function modulation, ROS can also influence gene expression profile by affecting intracellular signal transduction pathways. While several enzymatic (such as superoxide dismutase, catalase, glutathione peroxidase) and non enzymatic (such as 4-hydroxynonenal, decrease of glutathione, vitamin E, vitamin C, malondialdehyde) markers of chronic oxidative stress in liver are well known, early protein targets of oxidative injury are yet not well defined. Identification of these markers will enable early detection of liver diseases and will allow monitoring the degree of liver damage, the re-
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影响因子：
3.8
作者：
Raza, Haider;John, Annie
通讯作者：
John, Annie
影响因子：
29.4
作者：
M. Wheeler;Hiroshi Kono;Ming Yin;Ivan Rusyn;M. Froh;H. Connor;Ronald P. Mason;R. Samulski;R. G. Thurman
通讯作者：
M. Wheeler;Hiroshi Kono;Ming Yin;Ivan Rusyn;M. Froh;H. Connor;Ronald P. Mason;R. Samulski;R. G. Thurman
影响因子：
14.9
作者：
G. Tell;Alessandro Zecca;L. Pellizzari;P. Spessotto;A. Colombatti;M. Kelley;G. Damante;C. Pucillo
通讯作者：
G. Tell;Alessandro Zecca;L. Pellizzari;P. Spessotto;A. Colombatti;M. Kelley;G. Damante;C. Pucillo
影响因子：
29.4
作者：
Okuda, M;Li, K;Weinman, SA
通讯作者：
Weinman, SA