VACCINATION WITH A PLASMID VECTOR CARRYING THE RABIES VIRUS GLYCOPROTEIN GENE INDUCES PROTECTIVE IMMUNITY AGAINST RABIES VIRUS
VACCINATION WITH A PLASMID VECTOR CARRYING THE RABIES VIRUS GLYCOPROTEIN GENE INDUCES PROTECTIVE IMMUNITY AGAINST RABIES VIRUS
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DOI：
10.1006/viro.1994.1105
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发表时间：
1994-02-15
期刊：
影响因子：
3.7
通讯作者：
ERTL, HCJ
中科院分区：
文献类型：
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作者：
XIANG, ZQ;SPITALNIK, S;ERTL, HCJ
在C3 H/He小鼠中测试了在SV 40早期启动子控制下表达狂犬病病毒糖蛋白的质粒载体（称为pSG5rab.gp）诱导狂犬病病毒特异性免疫应答。用pSG5rab.gp载体肌肉注射免疫的小鼠产生了狂犬病病毒糖蛋白特异性溶细胞性T细胞、淋巴因子分泌的TH 1亚群T辅助细胞和狂犬病病毒中和抗体。用pSG5rab.gp载体接种的小鼠被完全保护免于随后的狂犬病病毒攻击。
A plasmid vector, termed pSG5rab.gp, that expresses the rabies virus glycoprotein under the control of an SV40 early promoter, was tested in C3H/He mice for induction of rabies virus-specific immune responses. Mice immunized intramuscularly with the pSG5rab.gp vector developed rabies virus glycoprotein-specific cytolytic T cells, lymphokinesecreting T helper cells of the TH1subset, and rabies virus-neutralizing antibodies. Mice vaccinated with the pSG5rab.gp vector were fully protected against a subsequent challenge with rabies virus.