The Clinical Impact and Cost-Effectiveness of Essential Oils and Aromatherapy for the Treatment of Acne Vulgaris: A Protocol for a Randomized Controlled Trial
The Clinical Impact and Cost-Effectiveness of Essential Oils and Aromatherapy for the Treatment of Acne Vulgaris: A Protocol for a Randomized Controlled Trial
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DOI：
10.1089/acm.2013.0137
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发表时间：
2014-05-01
影响因子：
2.6
通讯作者：
Segal, Leonie
中科院分区：
文献类型：
--
作者：
Agnew, Tamara;Leach, Matthew;Segal, Leonie
背景资料：痤疮是一种流行的、慢性的、有时是严重的皮肤病，估计影响85%的青少年和50%的20岁以上的成年人。痤疮的心理社会影响可能是相当大的，往往持续很长时间后，身体症状解决。虽然有效的痤疮药物是可用的，大多数表现出不良反应的档案，可以离开病人很少有效的治疗选择。新出现的证据表明，植物精油可能是一种生物学合理的治疗痤疮，虽然高质量的证据的有效性和安全性是lacked.Objective：研究的临床有效性和成本效益的精油和芳香疗法的治疗痤疮。设计：这个随机，等待名单对照试验将有三个平行组; 192名年龄在16-45岁之间的寻常痤疮参与者将主要通过南澳阿德莱德的八个技术和继续教育校区招募。参与者将被随机分配到标准精油混合，定制芳香疗法治疗，或等待名单控制。将在基线和第6周和第12周使用利兹痤疮分级系统、生活质量评估-8维工具和痤疮特异性生活质量工具评估痤疮的身体和心理社会症状的变化。治疗费用将根据资源投入和单位成本计量，并将限于痤疮治疗。临床效果和成本效益将进行比较，每个干预措施和对通常的护理，使用标准的健康经济techniques.Conclusions：精油和芳香疗法在治疗痤疮的有效性提供高质量的证据，可以帮助消费者作出更明智的选择痤疮管理。从这项研究中获得的见解也将有助于补充医学的学术领域，特别是芳香疗法，其证据基础非常有限。
Background: Acne is a prevalent, chronic, and sometimes severe skin disorder affecting an estimated 85% of adolescents and 50% of adults older than age 20 years. The psychosocial implications of acne can be considerable, often continuing long after physical symptoms resolve. Although effective acne medications are available, most exhibit adverse-effect profiles that can leave the patient with few effective treatment options. Emerging evidence indicates that plant-derived essential oils may be a biologically plausible treatment for acne, although high-quality evidence of effectiveness and safety is lacking.Objective: To examine the clinical effectiveness and cost-effectiveness of essential oils and aromatherapy for the treatment of acne.Design: This randomized, wait-list controlled trial will have three parallel groups; 192 participants with acne vulgaris, aged 16-45 years, will be recruited primarily through eight Technical and Further Education campuses across Adelaide, South Australia. Participants will be randomly assigned to standard essential oil blend, customized aromatherapy treatment, or wait-list control. Changes in the physical and psychosocial symptoms of acne will be assessed at baseline and 6 and 12 weeks by using the Leeds Acne Grading System, Assessment of Quality of Life-8 Dimension instrument, and Acne-Specific Quality of Life instrument. Costs of treatment will be measured on the basis of resource inputs and unit costs and will be limited to acne treatment. The clinical effectiveness and cost-effectiveness will be compared between each intervention and against usual care, using standard health economic techniques.Conclusions: The provision of high-quality evidence of the effectiveness of essential oils and aromatherapy in the treatment of acne may help consumers make better-informed choices about acne management. Insights gained from this research will also contribute to the academic field of complementary medicine, specifically aromatherapy, for which the evidence base is extremely limited.