Frequency of development of idiopathic dilated cardiomyopathy among relatives of patients with idiopathic dilated cardiomyopathy
Frequency of development of idiopathic dilated cardiomyopathy among relatives of patients with idiopathic dilated cardiomyopathy
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DOI：
10.1016/s0002-9149(03)00341-2
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发表时间：
2003-06-01
影响因子：
2.8
通讯作者：
Driscoll, DJ
中科院分区：
文献类型：
--
作者：
Michels, VV;Olson, TM;Driscoll, DJ
对1987年至1992年参加家庭研究的亲属进行了回顾性研究。有2个原始系列;第一个包括101例IDC患者及其一级亲属。如前所述，1该系列中的索引患者在他们到马约诊所接受心脏病学护理后被顺序确定，而不考虑家族史（以下称为“索引系列”）。这些患者或其亲属入组本研究时未采用遗传筛查标准。第二个系列包括12名在第一个系列之前因怀疑家族性IDC而转诊的患者（以下简称“选定系列”）。在两个系列的原始研究中，所有一级亲属都被邀请进行评估，无论该亲属是否患有或怀疑患有心脏病。在最初的研究中，对所有参与亲属的评估包括病史、心电图、二维和M型超声心动图的审查。患者和亲属IDC的诊断标准是左心室（LV）射血分数（EF）> 50%，LV大小为年龄和体型的第95百分位数，但未达到第95百分位数。
A retrospective study was conducted of relatives who had been enrolled in family studies from 1987 to 1992. There were 2 original series; the first included 101 patients with IDC patients and their first-degree relatives. As described previously, 1 the index patients in this series were sequentially ascertained after they had presented to the Mayo Clinic for cardiology care without regard to family history (hereafter referred to as the “unselected series”). No genetic screening criteria were applied for these patients or their relatives to enroll in this study. The second series included 12 patients referred before the unselected series because of suspected familial IDC (hereafter referred to as the “selected series”).In the original study of both series, all first-degree relatives had been invited for evaluation regardless of whether the relative had, or was suspected to have had, heart disease. Evaluations of all participating relatives in the original study included review of medical histories, electrocardiograms, and 2-dimensional and M-mode echocardiograms. Criteria for a diagnosis of IDC in patients and relatives were a left ventricular (LV) ejection fraction (EF) of 50% and LV size 95th percentile for age and body size, but pa-