BLOOD ETHANOL CONCENTRATION FROM EARLY POSTNATAL EXPOSURE - EFFECTS ON MEMORY-BASED LEARNING AND HIPPOCAMPAL NEUROANATOMY IN INFANT AND ADULT-RATS
BLOOD ETHANOL CONCENTRATION FROM EARLY POSTNATAL EXPOSURE - EFFECTS ON MEMORY-BASED LEARNING AND HIPPOCAMPAL NEUROANATOMY IN INFANT AND ADULT-RATS
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DOI：
10.1037/0735-7044.106.1.51
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发表时间：
1992-02-01
影响因子：
1.9
通讯作者：
AMSEL, A
中科院分区：
文献类型：
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作者：
GREENE, PL;DIAZGRANADOS, JL;AMSEL, A
出生后早期暴露于乙醇（EtOH）导致每日血乙醇浓度（BEC）峰值，阻碍了单模式交替（PA）的习得，这是一种基于记忆的辨别学习，并与脑重量、海马细胞数量和CA1面积的减少有关。这些行为和神经解剖学上的影响一直持续到年轻的成年期。在PA辨别方面，与低峰条件和对照条件相比，出生后暴露于高峰EtOH条件下，在60秒内损害了PA的获得，但在30秒内没有损害。这些结果为海马参与中期记忆提供了进一步的证据，并表明出生后早期EtOH是一种行为和神经解剖学上的致畸物，特别是当BEC相对较高时。
Early postnatal exposure to ethanol (EtOH) that results in daily high-peak blood ethanol concentration (BEC) retarded the acquisition of single-patterned alternation (PA), a kind of memory-based discrimination learning, and was related to reduced brain weight, hippocampal cell number, and CA1 area in infant rats. These behavioral and neuroanatomical effects survived into young adulthood. On the PA discrimination, in both pups and young adults, postnatal exposure to high-peak EtOH conditions, in relation to low-peak and control conditions, impaired the acquisition of PA at 60-s but not at 30-s intertrial intervals. These results provide further evidence of hippocampal involvement in intermediate-term memory and indicate that early postnatal EtOH is a behavioral and neuroanatomical teratogen, particularly when the BEC is relatively high.