Distinct lateral inhibitory circuits drive parallel processing of sensory information in the mammalian olfactory bulb
Distinct lateral inhibitory circuits drive parallel processing of sensory information in the mammalian olfactory bulb
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DOI：
10.7554/elife.16039
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发表时间：
2016-06-28
期刊：
影响因子：
7.7
通讯作者：
Urban, Nathan N.
中科院分区：
文献类型：
--
作者：
Geramita, Matthew A.;Burton, Shawn D.;Urban, Nathan N.
将感觉信息分解成平行的通路是感觉系统中的一种常见策略。然而，这些平行通路中的电路是如何组成以维持甚至增强特定刺激特征的编码的，人们还知之甚少。在这里，我们研究了小鼠嗅觉系统的二尖瓣细胞和丛生细胞形成的平行路径，并表征了这些细胞类型通过不同的侧抑制电路出现的特征选择性。我们发现二尖瓣细胞和簇生细胞之间活性依赖的侧向抑制的差异可能反映了新描述的深层和浅层颗粒细胞激活的差异。模拟表明，这些电路级的差异使二尖瓣细胞和簇生细胞在不同的浓度范围内能够最好地区分气味，这表明分离关于不同刺激强度范围的信息可能是这些平行感觉通路的重要功能。
Splitting sensory information into parallel pathways is a common strategy in sensory systems. Yet, how circuits in these parallel pathways are composed to maintain or even enhance the encoding of specific stimulus features is poorly understood. Here, we have investigated the parallel pathways formed by mitral and tufted cells of the olfactory system in mice and characterized the emergence of feature selectivity in these cell types via distinct lateral inhibitory circuits. We find differences in activity-dependent lateral inhibition between mitral and tufted cells that likely reflect newly described differences in the activation of deep and superficial granule cells. Simulations show that these circuit-level differences allow mitral and tufted cells to best discriminate odors in separate concentration ranges, indicating that segregating information about different ranges of stimulus intensity may be an important function of these parallel sensory pathways.