Molecular Mechanisms of Myoblast Fusion Across Species
Molecular Mechanisms of Myoblast Fusion Across Species
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DOI：
10.1007/978-94-007-0763-4_8
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Pavlath, Grace K.
中科院分区：
文献类型：
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作者：
Simionescu, Adriana;Pavlath, Grace K.
骨骼肌的发育、生长和再生依赖于成肌细胞祖细胞在一系列有序步骤中相互融合的能力。而导致多核肌纤维形成的细胞步骤在几种模式生物中是保守的，分子调控因子可能会有所不同。了解调节果蝇（果蝇）、斑马鱼（斑马鱼）和小家鼠（小鼠）成肌细胞融合的共同和不同机制，可以比任何这些模型单独提供的更好地了解成肌细胞融合过程。从简单到更复杂的生物体中解读成肌细胞融合的机制是骨骼肌生物学的根本兴趣，并可能为影响肌肉的各种疾病提供治疗途径。
Skeletal muscle development, growth and regeneration depend on the ability of progenitor myoblasts to fuse to one another in a series of ordered steps. Whereas the cellular steps leading to the formation of a multinucleated myofiber are conserved in several model organisms, the molecular regulatory factors may vary. Understanding the common and divergent mechanisms regulating myoblast fusion in Drosophila melanogaster (fruit fly), Danio rerio (zebrafish) and Mus musculus (mouse) provides a better insight into the process of myoblast fusion than any of these models could provide alone. Deciphering the mechanisms of myoblast fusion from simpler to more complex organisms is of fundamental interest to skeletal muscle biology and may provide therapeutic avenues for various diseases that affect muscle.