Vasoconstrictors in Spinal Anesthesia with Tetracaine—A Comparison of Epinephrine and Phenylephrine
Vasoconstrictors in Spinal Anesthesia with Tetracaine—A Comparison of Epinephrine and Phenylephrine
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丁卡因脊髓麻醉中的血管收缩剂——肾上腺素和去氧肾上腺素的比较
作者：
Mercedes A. Conception;R. Maddi;D. Francis;A. Rocco;E. Murray;B. Covino
在50名骨科患者中进行了一项随机双盲研究，以确定肾上腺素和苯肾上腺素对鞘内注射丁卡因的麻醉特性的影响。研究了每种血管收缩剂的两种剂量：0.2 mg肾上腺素、0.3 mg肾上腺素、1 mg苯肾上腺素和2 mg苯肾上腺素。结果表明，所用剂量的两种血管收缩剂均显著延长了由蛛网膜下施用丁卡因产生的感觉麻醉和运动阻滞的持续时间。在等效剂量下，肾上腺素和苯肾上腺素延长脊髓麻醉持续时间的能力之间没有差异。
A randomized double-blind, study was conducted in 50 orthopedic patients to determine the effect of epinephrine and phenylephrine on the anesthetic properties of intrathecally administered tetracaine. Two doses of each vasoconstrictor agent were studied: 0.2 mg of epinephrine, 0.3 mg of epinephrine, 1 mg of phenylephrine, and 2 mg of phenylephrine. The results show that both vasoconstrictor agents in the doses used significantly prolong duration of sensory anesthesia and motor blockade produced by the subarachnoid administration of tetracaine. At equipotent doses no differences existed between the ability of epinephrine and phenylephrine to prolong the duration of spinal anesthesia produced by detracting.