Definitive chemoradiotherapy for patients with malignant stricture due to T3 or T4 squamous cell carcinoma of the oesophagus.
Definitive chemoradiotherapy for patients with malignant stricture due to T3 or T4 squamous cell carcinoma of the oesophagus.
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由于食管的T3或T4鳞状细胞癌引起的恶性狭窄患者的明确化学放射疗法。
DOI：
10.1038/sj.bjc.6600684
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发表时间：
2003-01-13
影响因子：
8.8
通讯作者：
Mitamura K
中科院分区：
文献类型：
--
作者：
Kaneko K;Ito H;Konishi K;Kurahashi T;Ito T;Katagiri A;Yamamoto T;Kitahara T;Mizutani Y;Ohtsu A;Mitamura K
我们回顾性研究了同步放化疗治疗食管鳞状细胞癌引起的严重吞咽困难患者的有效性和可行性。对57例包含M1淋巴结（LYM）疾病的T3或T4疾病患者进行同步放化疗。化疗包括在第1 - 5天和第8 - 12天持续输注5-氟尿嘧啶（5-FU）400 mg m − 2 24 h − 1，并在第1天和第8天输注顺铂（CDDP）40 mg m − 2 2 h。放射治疗的剂量为30戈伊，在15个部分的纵膈同时给予化疗。疗程为3周，停药1~2周，共治疗2次，放疗总剂量60戈伊，随后给予2个或2个以上疗程的5-FU和CDDP。总的来说，24例患者（42%）达到完全缓解，3年生存率为19%。主要毒性为白细胞减少和食管炎，有2例（4%）治疗相关死亡。相比之下，22例T3疾病患者的生存时间长于35例T4疾病患者（P = 0.001）;然而，15例M1 LYM疾病患者的生存率与42例无M1 LYM疾病患者的生存率无显著差异（P = 0.3545）。我们的研究结果表明，明确的放化疗是潜在的治疗局部晚期食管癌恶性狭窄。用该方案治疗的患者的疗效和生存率与T因子有关。
We retrospectively investigated the efficacy and feasibility of concurrent chemoradiotherapy for patients with severe dysphagia caused by oesophageal squamous cell carcinoma. Concurrent chemoradiotherapy was performed in 57 patients with T3 or T4 disease containing M1 lymph node (LYM) disease. Chemotherapy consisted of protracted infusion of 5-fluorouracil (5-FU) 400 mg m−2 24 h−1 on days 1–5 and 8–12, combined with 2-h infusion of cisplatin (CDDP) 40 mg m−2 on days 1 and 8. Radiation treatment at a dose of 30 Gy in 15 fractions of the mediastinum was administered concomitantly with chemotherapy. A course schedule with 3-week treatment and a 1 to 2-week break was applied twice, with a total radiation dose of 60 Gy, followed by two or more courses of 5-FU and CDDP. In all, 24 patients (42%) achieved a complete response, and the 3-year survival rate was 19%. Major toxicities were leukocytopenia and oesophagitis, and there were two (4%) treatment-related deaths. In contrast, 22 patients with T3 disease survived longer than 35 patients with T4 disease (P=0.001); however, the survival rate in 15 patients with M1 LYM disease did not differ significantly from that in 42 patients without M1 LYM disease (P=0.3545). Our results indicate that definitive chemoradiotherapy is potentially curative for locally advanced oesophageal carcinoma with malignant stricture. The efficacy and survival of patients treated with this regimen are related to the T factor.
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DOI：
10.1073/pnas.83.23.8923
发表时间：
1986-12-01
影响因子：
11.1
作者：
SCANLON, KJ;NEWMAN, EM;PRIEST, DG
通讯作者：
PRIEST, DG
影响因子：
19.7
作者：
Curtin, HD;Ishwaran, H;McNeil, BJ
通讯作者：
McNeil, BJ
影响因子：
7.7
作者：
KOZAREK, RA;BALL, TJ;PATTERSON, DJ
通讯作者：
PATTERSON, DJ
影响因子：
7.7
作者：
FLEISCHER, DE;BULLHENRY, K
通讯作者：
BULLHENRY, K
DOI：
10.1016/0360-3016(94)00449-u
发表时间：
1995-07-15
影响因子：
7
作者：
BURMEISTER, BH;DENHAM, JW;WALKER, QJ
通讯作者：
WALKER, QJ