Macular sub-layer thinning and association with pulmonary function tests in Amyotrophic Lateral Sclerosis.
Macular sub-layer thinning and association with pulmonary function tests in Amyotrophic Lateral Sclerosis.
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DOI：
10.1038/srep29187
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发表时间：
2016-07-07
影响因子：
4.6
通讯作者：
Fawzi AA
中科院分区：
文献类型：
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作者：
Simonett JM;Huang R;Siddique N;Farsiu S;Siddique T;Volpe NJ;Fawzi AA
肌萎缩侧索硬化症(ALS)是一种复杂的神经退行性疾病，可累及前视通路。在这项研究中，我们比较了ALS患者和健康对照组的黄斑结构，并检查了黄斑亚层厚度测量与肺功能测试和病程之间的相关性。ALS患者接受光学相干断层扫描(OCT)，以获得右眼的黄斑立方体扫描。年龄匹配的健康受试者的黄斑立方体OCT数据由OCT阅读中心提供。使用半自动视网膜分割软件对黄斑各亚层进行量化。从ALS患者的电子病历中回顾收集肺功能测试和症状出现的时间。与健康对照组相比，肌萎缩侧索硬化症患者黄斑视网膜神经纤维层明显变薄(P <； 0.05)。在ALS队列中，黄斑和其他亚层的总厚度没有减少。黄斑视网膜神经纤维层厚度与用力肺活量%、预计1秒用力呼气量%呈正相关(P <； 0.05)。总之，OCT测量结果的分析支持ALS患者的前视通路受累。黄斑视网膜神经纤维层的细微结构变薄与肺功能测试有关。
Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder that may have anterior visual pathway involvement. In this study, we compare the macular structure of patients with ALS to healthy controls, and examine correlations between macular sub-layer thickness measurements and pulmonary function tests and disease duration. ALS patients underwent optical coherence tomography (OCT) imaging to obtain macular cube scans of the right eye. Macular cube OCT data from age-matched healthy subjects were provided by the OCT reading center. Semi-automated retinal segmentation software was used to quantify macular sub-layers. Pulmonary function tests and time since symptom onset were collected retrospectively from the electronic medical records of ALS patients. Macular retinal nerve fiber layer was significantly thinner in ALS patients compared to healthy controls (P < 0.05). Total macular and other sub-layer thicknesses were not reduced in the ALS cohort. Macular retinal nerve fiber layer thickness positively correlated with forced vital capacity % predicted and forced expiratory volume in 1 second % predicted (P < 0.05). In conclusion, analysis of OCT measurements supports the involvement of the anterior visual pathway in ALS. Subtle structural thinning in the macular retinal nerve fiber layer correlates with pulmonary function tests.