PHYSIOLOGICAL IDENTIFICATION OF JAW-MOVEMENT-RELATED NEURONS IN THE TRIGEMINAL NUCLEUS OF CATS
PHYSIOLOGICAL IDENTIFICATION OF JAW-MOVEMENT-RELATED NEURONS IN THE TRIGEMINAL NUCLEUS OF CATS
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DOI：
10.3109/08990229409028860
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发表时间：
1994-01-01
影响因子：
0.9
通讯作者：
WAX, TD
中科院分区：
文献类型：
--
作者：
CAPRA, NF;RO, JY;WAX, TD
虽然在三叉神经脑干核的大部分区域已经发现了对下颌运动有反应的神经元，但对于这些信息是如何传递到丘脑并最终传递到皮层以实现动觉功能和感觉运动整合的，我们知之甚少。目前的细胞外记录实验表明，成年猫大量的运动相关信息是通过内插亚核（V(i)）的尾侧部分传递到丘脑的。采用垂直下颌位移、自然机械刺激和咬肌神经电刺激来确定运动相关神经元的感受野和反应特性。在161个单元中观察到与运动相关的反应。这些单位的感受野位于咬肌、其他深层结构、毛状皮肤、口腔粘膜或这些结构的某些组合（即收敛）。对咬肌神经刺激产生反应的单元潜伏期在1.0 ~ 20 msec之间，这表明一些运动相关的信息是由较小直径的肌肉传入神经提供的。运动反应为强直或相性。强直单元在颌部某些部位连续放电；其中一些对下颌位移表现出“动态”反应。只有当下巴移动到一个特定的位置时，相单位才会活跃，或者表现出增加的活动。通过对侧丘脑腹后内侧核（VPM）的刺激，激活了71个运动相关单元。脑干记录部位多位于面肌运动核尾极与臀部之间的V(i)背侧。尾侧V(i)的神经元可能对面部动觉很重要。这支持了当前的观点，即这种复合感官体验包括来自多种外围输入的信息的整合。
Although neurons responsive to jaw movements have been identified in most parts of the trigeminal brainstem nuclei, little is known about how this information is relayed to the thalamus and ultimately to the cortex for kinesthetic functions and sensorimotor integration. The present extracellular recording experiments showed that a substantial amount of movement-related information is relayed to the thalamus through the caudal part of subnucleus interpolaris (V(i)) in adult cats. Vertical jaw displacements, natural mechanical stimuli, and electrical stimulation of the masseter nerve were used to determine the receptive fields and response properties of movement-related neurons. Movement-related responses were observed in 161 units. The receptive fields of these units were located in the masseter muscle, other deep structures, hairy skin, oral mucosa, or some combination of these structures (i.e., convergent). The latency of units responding to masseter nerve stimulation ranged from 1.0 msec to 20 msec, which suggested that some movement-related information was provided by smaller-diameter muscle afferents. Movement responses were either tonic or phasic. Tonic units showed continuous firing at some jaw position; some of these showed a ''dynamic'' response to jaw displacement. Phasic units were only active, or showed increased activity, when the jaw moved through a specific position. Seventy-one movement-related units were activated by stimulation from the contralateral ventroposteromedial nucleus (VPM) of the thalamus. Most of the brainstem recording sites were located in the dorsal part of V(i) between the caudal pole of the facial motor nucleus and the obex. Neurons in caudal V(i) may be important for facial kinesthesia. This supports current ideas that this composite sensory experience involves integration of information from many types of peripheral inputs.