T1ρ and T2 mapping reveal the in vivo extracellular matrix of articular cartilage
T1ρ and T2 mapping reveal the in vivo extracellular matrix of articular cartilage
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DOI：
10.1002/jmri.22811
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发表时间：
2012-01-01
影响因子：
4.4
通讯作者：
Mizuta, Hiroshi
中科院分区：
文献类型：
--
作者：
Nishioka, Hiroaki;Hirose, Jun;Mizuta, Hiroshi
目的：探讨细胞外基质（ECM）的变化与T1？和T2值。ECM由蛋白多糖（PG）、胶原和水组成。目前还不清楚ECM成分中的哪一种影响T1？材料与方法：20例膝关节骨性关节炎患者术前均行关节镜下T-1 rho和T-2标测。在全膝关节置换术期间从切除的胫骨平台采集的骨软骨样本与患者膝关节的MRI一致。参数包括软骨退变的组织学分级、糖胺聚糖（GAG）含量（其构成PG）、胶原各向异性的存在和水含量与T-1 rho和T-2值沿着进行评价，并且使用多元回归分析进行统计分析。T-1 rho和T-2值与软骨退变程度显著相关结论：T-1 rho和T-2值反映了软骨的GAG含量，可作为软骨退变的指标。使用这些参数可以促进软骨退变的非侵入性诊断和评估。
Purpose: To determine the relationship between changes in the extracellular matrix (ECM) and T1? and T2 values in vivo. The ECM is composed of proteoglycan (PG), collagen, and water. It has been unclear which of the ECM constituents affects T1? and T2 mapping in living human cartilage.Materials and Methods: Sagittal T-1 rho and T-2 maps were preoperatively obtained from 20 knee osteoarthritis patients. Osteochondral samples harvested from the resected tibial plateaus during total knee arthroplasty were consistent with the MRIs of the patients' knees. Parameters that included histological grading of cartilage degeneration, glycosaminoglycan (GAG) content (which constitutes PG), presence of collagen anisotropy and water content were evaluated along with T-1 rho and T-2 values, and statistical analysis was performed using multiple regression analysis.Results: T-1 rho and T-2 values were significantly correlated with the degree of cartilage degeneration (beta = 0.397 and 0.357, respectively) and the GAG content (beta = 0.340 and -0.244, respectively).Conclusion: The present study demonstrated that T-1 rho and T-2 values reflect the GAG content of the cartilage and can indicate cartilage degeneration in vivo. Use of these parameters can facilitate the noninvasive diagnosis and evaluation of cartilage degeneration.