Associations Between Fast-Food Consumption and Body Mass Index: A Cross-Sectional Study in Adult Twins.
Associations Between Fast-Food Consumption and Body Mass Index: A Cross-Sectional Study in Adult Twins.
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DOI：
10.1017/thg.2015.33
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Duncan GE
中科院分区：
文献类型：
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作者：
Cohen-Cline H;Lau R;Moudon AV;Turkheimer E;Duncan GE
肥胖在美国是一个严重的健康问题，并且与许多慢性疾病有关。以前的研究将不良的饮食习惯与肥胖联系起来。这项横断面研究的目的是确定身体质量指数（BMI）和快餐消费之间的关系，其中669同性成年双胞胎对居住在普吉特湾地区周围西雅图，华盛顿。我们计算了BMI和快餐消费的双对相关性。接下来，我们使用广义估计方程（GEE）回归BMI对快餐消费的影响，并最终估计了与快餐消费差异相关的BMI对内差异，这控制了一对双胞胎之间共享的所有潜在遗传和环境特征。同卵双胞胎（同卵双胞胎; MZ）和异卵双胞胎（异卵双胞胎; DZ）的快餐消费的双胞胎对相关性相似，但MZ的BMI显著高于DZ双胞胎。在未经调整的GEE模型中，更大的快餐消费与更大的BMI相关。对于双胞胎和同卵双胞胎，在任何模型中，快餐消费和BMI的配对差异之间都没有关联。相比之下，DZ双胞胎中快餐消费和BMI的配对差异之间存在显着关联，表明遗传因素在观察到的关联中发挥了作用。因此，尽管快餐消费本身的差异在很大程度上是由环境因素驱动的，但这种特定饮食行为与BMI之间的整体关联在很大程度上是由于遗传因素。
Obesity is a substantial health problem in the United States, and is associated with many chronic diseases. Previous studies have linked poor dietary habits to obesity. This cross-sectional study aimed to identify the association between body mass index (BMI) and fast-food consumption among 669 same-sex adult twin pairs residing in the Puget Sound region around Seattle, Washington. We calculated twin-pair correlations for BMI and fast-food consumption. We next regressed BMI on fast-food consumption using generalized estimating equations (GEE), and finally estimated the within-pair difference in BMI associated with a difference in fast-food consumption, which controls for all potential genetic and environment characteristics shared between twins within a pair. Twin-pair correlations for fast-food consumption were similar for identical (monozygotic; MZ) and fraternal (dizygotic; DZ) twins, but were substantially higher in MZ than DZ twins for BMI. In the unadjusted GEE model, greater fast-food consumption was associated with larger BMI. For twin pairs overall, and for MZ twins, there was no association between within-pair differences in fast-food consumption and BMI in any model. In contrast, there was a significant association between within-pair differences in fast-food consumption and BMI among DZ twins, suggesting that genetic factors play a role in the observed association. Thus, although variance in fast-food consumption itself is largely driven by environmental factors, the overall association between this specific eating behavior and BMI is largely due to genetic factors.