Semiconducting Oligomer Nanoparticles as an Activatable Photoacoustic Probe with Amplified Brightness for In Vivo Imaging of pH
Semiconducting Oligomer Nanoparticles as an Activatable Photoacoustic Probe with Amplified Brightness for In Vivo Imaging of pH
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DOI：
10.1002/adma.201505681
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发表时间：
2016-05-18
影响因子：
29.4
通讯作者：
Pu, Kanyi
中科院分区：
文献类型：
--
作者：
Miao, Qingqing;Lyu, Yan;Pu, Kanyi
一种基于半导体低聚物的可激活光声纳米探针，具有放大的亮度和pH传感能力，通过利用纳米掺杂同时在单个粒子内产生粒子内光诱导电子转移和分子内质子化来开发。这种有机纳米探针允许通过以相对低的剂量全身给药对活体小鼠肿瘤中的pH进行非侵入性实时比率光声成像。
An activatable photoacoustic nanoprobe based on a semiconducting oligomer with amplified brightness and pH-sensing capability is developed by taking advantage of nanodoping to simultaneously create both intraparticle photoinduced electron transfer and intramolecular protonation within a single particle. This organic nanoprobe permits non invasive real-time ratiometric photo acoustic imaging of pH in tumors in living mice through systemic administration at a relatively low dosage.