Progression of attachment loss is strongly associated with presence of the JP2 genotype of Aggregatibacter actinomycetemcomitans: a prospective cohort study of a young adolescent population
Progression of attachment loss is strongly associated with presence of the JP2 genotype of Aggregatibacter actinomycetemcomitans: a prospective cohort study of a young adolescent population
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DOI：
10.1111/jcpe.12209
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发表时间：
2014-03-01
影响因子：
6.7
通讯作者：
Haubek, Dorte
中科院分区：
文献类型：
--
作者：
Aberg, Carola Hoglund;Kwamin, Francis;Haubek, Dorte
目的：根据加纳青少年人群中聚集菌放线菌comitans JP2和非JP2基因型的存在，评估2年期间依恋丧失（AL）的进展。方法共纳入500例青少年，平均年龄13.2岁，SD1.5岁。2年后，397名（79.4%）患者再次进行牙周检查，包括测量AL。在2年前的基线检查中评估放线菌孢子虫JP2和非JP2基因型的携带者状况。结果携带放线菌单胞菌JP2基因型的个体发生AL3mm的风险显著增加[相对风险(RR)=7.3]。JP2基因型阳性组（n=38）随访时平均AL和平均2年AL进展明显高于非JP2基因型放线菌comitans阳性组（n=169）和放线菌comitans阴性组（n=190）。JP2基因型与AL3mm的进展密切相关（OR=14.3）。然而，放线菌酵母的非jp2基因型也不太明显，与AL3mm的进展相关（OR=3.4）。结论：放线菌孢子虫JP2基因型与AL的进展密切相关。
Aim: To assess the progression of attachment loss (AL) during a 2-year period according to the presence of JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans in a Ghanaian adolescent population.MethodsA total of 500 adolescents (mean age 13.2years, SD1.5) were enrolled in the study. After 2years, 397 (79.4%) returned for a periodontal re-examination, including the measurement of AL. The carrier status of the JP2 and non-JP2 genotypes of A. actinomycetemcomitans was evaluated in a baseline examination 2years earlier.ResultsIndividuals who carried the JP2 genotype of A. actinomycetemcomitans had a significantly increased risk [relative risk (RR)=7.3] of developing AL3mm. The mean AL at the follow-up and the mean 2-year progression of AL were significantly higher in the JP2 genotype-positive group (n=38) compared with the group positive for the non-JP2 genotypes of A. actinomycetemcomitans (n=169), and the group of A. actinomycetemcomitans-negative individuals (n=190). The JP2 genotype was strongly associated with the progression of AL3mm (OR=14.3). The non-JP2 genotypes of A. actinomycetemcomitans were also, however, less pronounced, associated with the progression of AL3mm (OR=3.4).Conclusion: The JP2 genotype of A. actinomycetemcomitans is strongly associated with the progression of AL.