Platelet-derived growth factor (PDGF) signalling in cancer: rapidly emerging signalling landscape.
Platelet-derived growth factor (PDGF) signalling in cancer: rapidly emerging signalling landscape.
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DOI：
10.1002/cbf.3120
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发表时间：
2015-07
影响因子：
3.6
通讯作者：
Siddik ZH
中科院分区：
文献类型：
--
作者：
Farooqi AA;Siddik ZH
血小板源性生长因子（PDGF）介导的信号转导已成为研究最广泛和深入的生物学机制之一，据报道参与调节不同细胞类型的生长和存活。然而，越来越多的科学证据也强调时空控制的PDGF诱导的信号传导失调是癌症发展的基础。我们将这一多组分综述划分为最近发展的对不同癌症中PDGF信号失调的理解，以及PDGF受体如何被microRNA定量控制。此外，我们还总结了PDGFR治疗靶向的临床前研究所证明的最新进展。更好地了解PDGF诱导的细胞内信号在不同的癌症将有助于催化癌症生物学从一个分段的观点过渡到一个概念上的连续性。
Platelet-derived growth factor (PDGF)-mediated signalling has emerged as one of the most extensively and deeply studied biological mechanism reported to be involved in regulation of growth and survival of different cell types. However, overwhelmingly increasing scientific evidence is also emphasizing on dysregulation of spatio-temporally controlled PDGF-induced signalling as a basis for cancer development. We partition this multi-component review into recently developing understanding of dysregulation PDGF signalling in different cancers, how PDGF receptors are quantitatively controlled by microRNAs. Moreover, we also summarize most recent advancements in therapeutic targeting of PDGFR as evidenced by preclinical studies. Better understanding of the PDGF-induced intracellular signalling in different cancers will be helpful in catalysing the transition from a segmented view of cancer biology to a conceptual continuum.