Design and Preparation of New Palladium Precatalysts for C-C and C-N Cross-Coupling Reactions.
Design and Preparation of New Palladium Precatalysts for C-C and C-N Cross-Coupling Reactions.
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DOI：
10.1039/c2sc20903a
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发表时间：
2013
期刊：
影响因子：
8.4
通讯作者：
Buchwald SL
中科院分区：
文献类型：
--
作者：
Bruno NC;Tudge MT;Buchwald SL
制备了一系列以2-氨基联苯为骨架的膦配位钯预催化剂。研究了预催化剂缔合的不稳定卤化物（或拟卤化物）在钯配合物的形成和稳定性中的作用。发现用甲磺酸酯替代先前形式的预催化剂中的氯化物导致具有改善的溶液稳定性并且易于由更宽范围的膦配体制备的新类别的预催化剂。探讨了以前版本的precatalyst和这里报道的之间的差异。此外，后者的反应性检查在一系列的C-C和C-N键形成反应。
A series of easily prepared, phosphine-ligated palladium precatalysts based on the 2-aminobiphenyl scaffold have been prepared. The role of the precatalyst-associated labile halide (or pseudohalide) in the formation and stability of the palladacycle has been examined. It was found that replacing the chloride in the previous version of the precatalyst with a mesylate leads to a new class of precatalysts with improved solution stability and that are readily prepared from a wider range of phosphine ligands. The differences between the previous version of precatalyst and that reported here are explored. In addition, the reactivity of the latter is examined in a range of C-C and C-N bond forming reactions.