RTX toxin structure and function: a story of numerous anomalies and few analogies in toxin biology.
RTX toxin structure and function: a story of numerous anomalies and few analogies in toxin biology.
复制标题
RTX 毒素的结构和功能：毒素生物学中众多异常现象和很少类比的故事。
DOI：
10.1007/978-3-642-56508-3_5
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发表时间：
2001
影响因子：
--
通讯作者：
Welch,RA
中科院分区：
文献类型：
--
作者：
Welch,RA
本文综述了RTX家族细菌毒素的组成、结构和毒性机制的最新研究进展。我将不讨论他们的调节和不寻常的细胞外分泌机制。最近有一些研究者撰写的优秀综述，他们的研究集中在那些可以参考的主题上（Bailey et al. 1997; YoungandHolland 1999）。经过一个非常一般的审查，讨论是围绕13个关键问题和相关的假设涉及RTX毒素生物学。我将回顾支持或反驳这些假设的结果，同时对现有数据提出几种新的替代解释。正如这篇评论的标题所预示的那样，RTX毒素的生物学和生物化学提出了独特而困难的实验问题，我希望能为读者有效地阐明这些问题。
This review will cover recent advances in the knowledge of the composition, structure and toxic mechanisms of the important RTX family of bacterial toxins. I will not discuss their regulation and unusual mechanism of extracellular secretion. There are outstanding recent reviews written by investigators whose research is focused on those topics that can be consulted (Baileyet al. 1997;YoungandHolland1999). After a very general review, the discussion is organized around 13 critical questions and relevant hypotheses involving RTX toxin biology. I will review the results that support or refute these assumptions while proposing several new alternative interpretations of the available data. As foreshadowed in this review’s title, the biology and biochemistry of RTX toxins present unique and difficult experimental problems, which I hope will be effectively elucidated for the reader.