Marked N-acetylaspartate and choline metabolite changes in Parkinson's disease patients with mild cognitive impairment
Marked N-acetylaspartate and choline metabolite changes in Parkinson's disease patients with mild cognitive impairment
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DOI：
10.1016/j.parkreldis.2012.11.012
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发表时间：
2013-03-01
影响因子：
4.1
通讯作者：
Wang, Lijuan
中科院分区：
文献类型：
--
作者：
Nie, Kun;Zhang, Yuhu;Wang, Lijuan
背景：帕金森病（PD-MCI）的轻度认知功能损害日益受到重视，其诊断具有挑战性。为了分析早期诊断的可能生物标志物，我们通过质子磁共振波谱（MRS）研究了PD-MCI患者以及适当对照的不同脑区域的代谢物变化。对66例PD-MCI患者的枕叶、后扣带回、黑质和基底节进行了代谢研究，结果：PD-MCI患者枕叶N-乙酰天冬氨酸/肌酸（NAA/Cr）比值低于正常对照组（P < 0.05）; PD-MCI组扣带回后部胆碱/肌酸比值高于对照组和PD-CN组（均P < 0.05）。枕叶NAA/Cr比值降低与PD-CN（P < 0.05）和PD-MCI（P < 0.0001）相关，后扣带回Cho/Cr比值升高与PD-MCI相关（P <0.001）。
Background: The mild cognitive impairment in Parkinson's disease (PD-MCI) has received increasing attention, of which the diagnosis is challenging. To analyze the possible biomarkers for the early diagnosis, we investigated the metabolite changes in different brain regions of PD-MCI patients as well as appropriate controls by proton magnetic resonance spectroscopy (MRS).Methods: The metabolism in the occipital lobe, posterior cingulate, substantia nigra and basal ganglia was studied in 66 PD-MCI patients, 70 cognitively normal PD patients (PD-CN) and 74 healthy controls.Results: The N-acetylaspartate to creatine (NAA/Cr) ratio in the occipital lobe in PD-MCI patients was lower than that in healthy controls (P < 0.05). In contrast, the choline to creatine ratio in the posterior cingulate was higher in PD-MCI patients than in controls or PD-CN patients (both P < 0.05). No significant metabolite difference in the substantia nigra and basal ganglia was found. Furthermore, the decreases of the ratios of NAA/Cr in the occipital lobe were associated with PD-CN (P < 0.05) and PD-MCI (P < 0.0001) while the increase in the ratio of Cho/Cr in the posterior cingulate was associated with PD-MCI (P