Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
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DOI：
10.1097/ypg.0000000000000212
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发表时间：
2019-04-01
影响因子：
0.9
通讯作者：
Sundquist, Kristina
中科院分区：
文献类型：
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作者：
Li, Xinjun;Sjostedt, Cecilia;Sundquist, Kristina
在全基因组关联研究的时代，家族风险被用来估计疾病的遗传性和基因识别的成功率。我们想估计协会的42个自身免疫性疾病与注意力缺陷多动障碍（ADHD）之间的个人和家庭members.Participants和方法的可用性在瑞典的多代登记提供了可靠的访问，涵盖了上个世纪的家庭数据。一个开放的队列设计的疾病在个人和家庭成员获得通过链接到医院出院登记。结果在86 493例患者中，有自身免疫性疾病家族史者18 153例，有自身免疫性疾病家族史者18 153例。ADHD与一级亲属中的14种自身免疫性疾病相关，包括强直性脊柱炎（标准化发病率：1.13），乳糜泻（1.16）克罗恩病（1.07），1型糖尿病（1.19）、盘状红斑狼疮（1.26）、慢性肾小球肾炎（1.13），桥本/甲状腺功能减退症（1.11），狼疮样肝炎（1.44）、多发性硬化症（1.11）、牛皮癣（1.18），Reiter病（1.38）、类风湿性关节炎（1.07），干燥综合征结论几种自身免疫性疾病存在家族性关联，提示存在遗传共享性，对基因鉴定提出了挑战。版权所有（c）2018威科医疗集团All rights reserved.
Aims In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.Participants and methods The availability of a Multigeneration Register in Sweden provides reliable access to family data that covers the last century. An open cohort design of the diseases in individual and family members was obtained through linkage to the Hospital Discharge Register. Standardized incidence ratios were calculated as relative risks for ADHD in family members of affected patients compared with those without affected family members.Results Among a total of 86 493 patients, 18 153 had a family history of autoimmune diseases. ADHD was associated with 14 autoimmune diseases in the first-degree relatives, including ankylosing spondylitis (standardized incidence ratio: 1.13), celiac disease (1.16), Crohn's disease (1.07), diabetes mellitus type 1 (1.19), discoid lupus erythematosus (1.26), glomerular nephritis chronic (1.13), Hashimoto/hypothyroidism (1.11), lupoid hepatitis (1.44), multiple sclerosis (1.11), psoriasis (1.18), Reiter's disease (1.38), rheumatoid arthritis (1.07), Sjogren's syndrome (1.21), and ulcerative colitis (1.05).Conclusion Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification. Copyright (c) 2018 Wolters Kluwer Health, Inc. All rights reserved.