ANTIMICROBIAL ACTIVITY OF JUGLONE
ANTIMICROBIAL ACTIVITY OF JUGLONE
复制标题
DOI：
10.1002/ptr.2650040104
复制
发表时间：
1990-02-01
影响因子：
7.2
通讯作者：
HUFFORD, CD
中科院分区：
文献类型：
--
作者：
CLARK, AM;JURGENS, TM;HUFFORD, CD
新鲜浸渍的黑核桃（Juglans nigra）未成熟外壳的汁液多年来一直在民间医学中用于治疗局部真菌感染（例如癣）。有人提出，核桃壳的生物活性是由于存在简单的萘醌胡桃醌（5-羟基-1,4-萘醌），它是通过升华从未成熟的壳中分离出来的。由于未成熟核桃壳的新鲜汁液用于治疗癣，并且推测该活性是由于胡桃醌的存在而产生的，因此有兴趣确定胡桃醌与标准市售抗真菌剂相比的功效。通过评估胡桃醌和标准抗真菌药物克霉唑、三醋精、托萘酯、灰黄霉素、十一烯酸锌、硫化硒以及两种在研抗真菌抗生素（麦钱腺嘌呤和甲硫碘麦钱腺嘌呤）对两种皮肤癣菌（须毛癣菌和小孢子菌）的最低抑菌浓度（MIC）值来确定比较疗效。石膏。胡桃醌的 MIC 值表明它具有中等抗真菌活性，并且与某些市售抗真菌剂（例如十一烯酸锌和硫化硒）一样有效。
The juice of freshly macerated unripe hulls of the black walnut (Juglans nigra) has been used for many years in folk medicine as a treatment for localized, topical fungal infections such as ringworm. It has been proposed that the biological activity of the walnut hulls is due to the presence of the simple naphthoquinone, juglone (5‐hydroxy‐1,4‐naphthoquinone), which has been isolated from the unripe hulls by sublimation. Since the fresh juice of unripe walnut hulls is utilized for the treatment of ringworm, and since it has been speculated that the activity is due to the presence of juglone, it was of interest to determine the efficacy of juglone as compared to standard commercially available antifungal agents. The comparative efficacy was determined by evaluation of the minimum inhibitory concentration (MIC) values of juglone and the standard antifungal agents clotrimazole, triacetin, tolnaftate, griseofulvin, zinc undecylenate, selenium sulfide as well as two investigational antifungal antibiotics, liriodenine and liriodenine methiodide, for two dermatophytes,Trichophyton mentagrophytes and Microsporum gypseum. MIC values for juglone showed it to have moderate antifungal activity and to be as effective as certain commercially available antifungal agents such as zinc undecylenate and selenium sulfide.