Effectiveness of Haemophilus influenzae b conjugate vaccine on childhood pneumonia:: a case-control study in Brazil
Effectiveness of Haemophilus influenzae b conjugate vaccine on childhood pneumonia:: a case-control study in Brazil
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DOI：
10.1093/ije/dyh025
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发表时间：
2004-02-01
影响因子：
7.7
通讯作者：
Fabio, JLD
中科院分区：
文献类型：
--
作者：
de Andrade, ALSS;de Andrade, JG;Fabio, JLD
背景b型流感嗜血杆菌结合疫苗在减少b型流感嗜血杆菌脑膜炎方面效果显著。然而，在将疫苗引入常规方案后，关于其对儿童肺炎的影响的信息有限。这项研究评估了Hib结合疫苗在减少巴西中部地区婴儿社区获得性肺炎方面的有效性。方法在2000年5月至2001年8月期间，1293名参与者参加了一项配对的病例对照研究，纳入了持续的基于人群的肺炎前瞻性监测。病例(n=431)是根据世界卫生组织关于肺炎诊断的放射学诊断标准的放射学明确肺炎住院的2岁以下儿童。在同一社区的儿童中发现了两名以前没有因肺炎住院的对照组(n=862)，并按年龄层(+/-4个月)与病例匹配。结果儿童肺炎的最大危险因素是
Background The conjugate Haemophilus influenzae type b (Hib) vaccine has been highly efficacious in reducing type b H. influenzae meningitis. However, information is limited about its impact on childhood pneumonia after vaccine introduction into the routine programme. This study evaluated the effectiveness of Hib conjugate vaccine in the reduction of community-acquired pneumonia among infants in Central Brazil.Methods A matched case-control study was built into an ongoing prospective population-based surveillance of pneumonia, enrolling 1293 participants between May 2000 and August 2001. Cases (n = 431) were children less than or equal to2 years old hospitalized with radiologically definite pneumonia according to the World Health Organization standard criteria for the interpretation of radiographs for the diagnosis of pneumonia. Two controls (n = 862) without previous hospitalization for pneumonia were identified among children from the same neighbourhood and matched to cases by age stratum (+/-4 months). The Hib vaccination effectiveness was estimated as 1 minus odds ratio (OR).Results The greatest risk factor for pneumonia among children