MECHANISMS OF DEFENSE AGAINST PLASMODIUM-FALCIPARUM ASEXUAL BLOOD STAGES IN HUMANS
MECHANISMS OF DEFENSE AGAINST PLASMODIUM-FALCIPARUM ASEXUAL BLOOD STAGES IN HUMANS
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DOI：
10.1016/0165-2478(94)90118-x
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发表时间：
1994-07-01
影响因子：
4.4
通讯作者：
PERIGNON, JL
中科院分区：
文献类型：
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作者：
DRUILHE, P;PERIGNON, JL
基于观察到宿主-寄生虫免疫关系不仅取决于寄生虫种类，还取决于宿主，我们认为恶性疟原虫可以在人类中进行最好的研究。体内观察表明，人类对恶性疟原虫有一系列的免疫力：除了发挥主要作用的先天性非抗原特异性防御外，在连续的疟疾攻击后还获得了额外的防御机制。它们有助于实现各种免疫状态，如对脑型疟疾的获得性抗性、抗病免疫、品系特异性免疫，以及在高度流行或完全流行地区长时间接触后的宿主-寄生虫平衡，这是预防性免疫的特征。被动转移实验表明，IgG在弹药前发挥主要作用。我们回顾，一方面，在体外的证据表明，保护性抗体具有促进单核细胞依赖性抑制寄生虫生长（ADCI）的特征能力，另一方面，在体内的观察表明，这种防御机制可能是一个免疫基础的状态premunition。
Based on the observation that host-parasite immune relationships depend not only on the parasite species but also on the host, we consider that P. falciparum can be best studied in humans. In vivo observations suggest that there are in humans a series of immunities towards P. falciparum: besides innate non-antigen-specific defenses, which play a major role, additional defense mechanisms are acquired after consecutive malaria attacks. They contribute to realize such various states of immunity as acquired resistance to cerebral malaria, anti-disease immunity, strain-specific immunity, and, after a long time of exposure in hyper- or holoendemic areas, the host-parasite equilibrium characteristic of premunition. Passive transfer experiments have established that IgG play a major role in premunition. We review, on the one hand, in vitro evidences that protective antibodies have the characteristic capacity of promoting a monocyte-dependent inhibition of parasite growth (ADCI) and, on the other hand, the in vivo observations that suggest that this mechanism of defense could be one of the immune foundations of the state of premunition.